566661
SAG
≥95% (HPLC), liquid, smoothened agonist, Calbiochem®
别名:
InSolution Smoothened激动剂，SAG, SAG1.3溶液
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关于此项目
经验公式（希尔记法）:
C28H28ClN3OS · 2HCl · xH2O
分子量:
562.98 (anhydrous basis)
UNSPSC Code:
12352200
NACRES:
NA.77
产品名称
平滑激动剂，SAG, InSolution, ≥95%, 10 mM aqueous solution
assay
≥95% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
shipped in
wet ice
storage temp.
−20°C
Quality Level
Disclaimer
毒性：标准处理（A）
General description
一种细胞渗透性苯并噻吩化合物，可通过与Smo七次跨膜螺旋结构域（KD = 59 nM）相互作用，调节Smo与其下游效应器的偶联。显示可诱导刺猬通路激活（NIH 3T3衍生Shh-LIGHT2细胞中的EC50 ∼3 nM）并抵消环巴胺-KAAD（目录号239804）对Smo的抑制。据报道，在低浓度下作为激活剂，在极高浓度下作为抑制剂。
Other Notes
Meloni, A.R., et al. 2006.Mol.Cell.Biol.26, 7750.
Chen, W., et al. 2004.Science306, 2257.
Chen, J.K., et al. 2002.Proc.Natl.Acad.Sci. USA99, 14071.
Frank-Kamenetsky, M., et al. 2002.J. Biol.1, 10.
Chen, W., et al. 2004.Science306, 2257.
Chen, J.K., et al. 2002.Proc.Natl.Acad.Sci. USA99, 14071.
Frank-Kamenetsky, M., et al. 2002.J. Biol.1, 10.
Packaging
用惰性气体包装
Physical form
10 mM (500 µg/86 µl)Smoothened激动剂溶液，SAG (目录号566660)的H₂O溶液。
Preparation Note
初次融化后，等分并冷冻（-20°C）。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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