566321
Sirtinol
InSolution, ≥97%, inhibitor of sirtuin class of histone deacetylase (HDAC) activity
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别名:
InSolution Sirtinol, 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide, Sir Two Inhibitor Naphthol, SIRT1 Inhibitor I, SIRT1/2 Inhibitor I, SIRT2 Inhibitor III
经验公式（希尔记法）:
C26H22N2O2
分子量:
394.47
UNSPSC代码:
12352200
NACRES:
NA.77
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质量水平
检测方案
≥97% (HPLC)
形式
liquid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
运输
wet ice
储存温度
2-8°C
一般描述
A cell-permeable 2-hydroxy-1-napthaldehyde derivative that acts as a specific and a direct inhibitor of sirtuin class of histone deacetylase (HDAC) activity. Does not affect human HDAC1. Reported to block Sir2p transcriptional silencing activity in vivo (IC50 = 25 µM) and NAD-dependent HDAC activity in purified recombinant yeast Sir2p and human SIRT2 in vitro (IC50 = 68 µM and 38 µM, respectively).
生化/生理作用
Cell permeable: yes
Primary Target
ySir2
ySir2
Product does not compete with ATP.
Reversible: no
Target IC50: 48 µM, 131 µM and 58 µM for ySir2, hSIRT1 and hSIRT2, respectively
包装
Packaged under inert gas
警告
Toxicity: Irritant (B)
外形
A 10 mM (1 mg/254 µl) solution of Sirtinol (Cat. No. 566320) in DMSO.
重悬
Following initial thaw, aliquot and refrigerate (4°C).
其他说明
Mai, A., et al. 2005. J. Med. Chem.48, 7789.
Grozinger, C.M., et al. 2001. J. Biol. Chem.276, 38837.
Grozinger, C.M., et al. 2001. J. Biol. Chem.276, 38837.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Yi-Fan Lin et al.
iScience, 24(10), 103118-103118 (2021-10-09)
The mitochondrial unfolded protein response (UPRmt) is an organellar stress signaling pathway that functions to detect and restore disruption of mitochondrial proteostasis. The UPRmt is involved in a wide range of physiological and disease conditions, including aging, stem cell maintenance
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