566224
3Fax-Peracetyl Neu5Ac
≥98% (NMR), solid, sialytransferase inhibitor, Calbiochem®
别名:
唾液酸轉移酶抑制剂，3Fax-Peracetyl Neu5Ac
产品名称
唾液酸轉移酶抑制剂，3Fax-Peracetyl Neu5Ac, The Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac controls the biological activity of Sialyltransferase.
SMILES string
F[C@@H]1[C@@H]([C@H](C([C@@H]([C@@H](COC(C)=O)OC(C)=O)OC(C)=O)OC(C(OC)=O)1OC(C)=O)NC(C)=O)OC(C)=O
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
−70°C
Quality Level
Biochem/physiol Actions
主要靶标
唾液酸转移酶
唾液酸转移酶
可逆性：是
细胞可渗透性：是
Disclaimer
毒性：标准处理（A）
General description
一种细胞可渗透的唾液酸类似物，在细胞摄取后转化为轴向位置带有C3氟取代基的CMP-Neu5Ac（a href="http://www.emdmillipore.com/products/EMD_BIO-233264" target=_blank>233264）模拟物 ，以供体底物CMP-Neu5Ac-竞争方式有效抑制唾液酸转移酶。显示有效消除HL-60细胞表面SLeX表达（降低>95%；200 µM持续5天），导致细胞表面E-选择素和P-选择素结合显着降低（分别降低>95% 和>80%），没有影响细胞活力或增殖。
Other Notes
Rillahan, C., et al. 2012.Nat. Chem. Bio.8, 661.
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-70°C下可稳定保存至多3个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Bianca Saveria Fioretto et al.
Cells, 13(12) (2024-06-26)
Aberrant sialylation with overexpression of the homopolymeric glycan polysialic acid (polySia) was recently reported in fibroblasts from fibrotic skin lesions. Yet, whether such a rise in polySia levels or sialylation in general may be functionally implicated in profibrotic activation of
John Daly et al.
Blood advances, 6(11), 3352-3366 (2022-03-17)
Abnormal glycosylation is a hallmark of cancer, and the hypersialylated tumor cell surface facilitates abnormal cell trafficking and drug resistance in several malignancies, including multiple myeloma (MM). Furthermore, hypersialylation has also been implicated in facilitating evasion of natural killer (NK)
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Marlieke L M Jongsma et al.
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