跳转至内容
Merck
CN
所有图片(1)

主要文件

查看所有文档

565851

Sigma-Aldrich

NSC-87877

≥97% (HPLC), solid, SHP1/2 PTPase inhibitor, Calbiochem®

别名:

SHP1/2蛋白酪氨酸磷酸酶抑制剂，NSC-87877, 8-羟基-7-(6-磺基萘-2-基)二氮烯基-喹啉-5-磺酸，二钠盐，HePTP抑制剂II，PTP抑制剂XXV，PTP1B抑制剂IV，SHP1抑制剂I，SHP2抑制剂I

登录查看公司和协议定价
所有图片(1)

About This Item

经验公式（希尔记法）:
C19H11N3Na2O7S2
CAS号:
56932-43-5
分子量:
503.42
MDL编号:
MFCD00041863
UNSPSC代码:
12352200
NACRES:
NA.54

产品名称

SHP1/2蛋白酪氨酸磷酸酶抑制剂，NSC-87877, The SHP1/2 PTPase Inhibitor, NSC-87877, also referenced under CAS 56932-43-5, controls the biological activity of SHP1/2 PTPase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

质量水平

100

方案

≥97% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)
protect from light

颜色

red-brown

溶解性

water: 10 mg/mL

运输

ambient

储存温度

2-8°C

SMILES字符串

[Na+].[Na+].[S](=O)(=O)([O-])c1cc2c(cc(cc2)N\N=C3/C=C(c4c(nccc4)C/3=O)[S](=O)(=O)[O-])cc1

InChI

1S/C19H13N3O7S2.2Na/c23-19-16(10-17(31(27,28)29)15-2-1-7-20-18(15)19)22-21-13-5-3-12-9-14(30(24,25)26)6-4-11(12)8-13;;/h1-10,21H,(H,24,25,26)(H,27,28,29);;/q;2*+1/p-2/b22-16+;;

InChI key

YOGRUDWAJPVHEL-LLDDCTHSSA-L

一般描述

一种细胞渗透性7-氮杂-8-羟基喹啉化合物，作为SHP-1和SHP-2蛋白酪氨酸磷酸酶的有效催化靶向抑制剂（IC50分别为355 nM和318 nM）。它抑制PTP1B和HePTP的效力较低（IC50分别为1.69 µM和7.75 µM），并且比DEP1、CD45和LAR表现出>200倍的选择性。显示抑制HEK293细胞的基础和刺激SHP-2活性。

生化/生理作用

Cell permeable: yes
主要靶标
SHP1/2 PTPase
产物不与ATP竞争。
可逆：否
靶标IC50：针对SHP-1和SHP-2蛋白酪氨酸磷酸酶分别为355 nM和318 nM

包装

用惰性气体包装

警告

毒性：标准处理（A）

重悬

复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。

其他说明

Chen, L., et al. 2006.Mol.Pharmacol.70, 562.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

T Tao et al.
Oncogene, 36(44), 6119-6131 (2017-07-12)
Renal cell carcinoma (RCC) is one of the most aggressive urologic cancers, however, the mechanism on supporting RCC carcinogenesis is still not clear. By using gene expression profile analysis and functional clustering, PDZ domain-containing 1 (PDZK1) was revealed to be
Corleone S Delaveris et al.
ChemRxiv : the preprint server for chemistry (2021-01-21)
Severe cases of coronavirus disease 2019 (COVID-19), caused by infection with SARS-Cov-2, are characterized by a hyperinflammatory immune response that leads to numerous complications. Production of proinflammatory neutrophil extracellular traps (NETs) has been suggested to be a key factor in
Sofía C Khouili et al.
Cell reports, 33(9), 108468-108468 (2020-12-03)
Intracellular pathogens have evolved strategies to evade detection by cytotoxic CD8+ T lymphocytes (CTLs). Here, we ask whether Leishmania parasites trigger the SHP-1-FcRγ chain inhibitory axis to dampen antigen cross-presentation in dendritic cells expressing the C-type lectin receptor Mincle. We
Pengcheng Shang et al.
Nature communications, 14(1), 2615-2615 (2023-05-06)
Mammalian orthoreovirus (reovirus) infects most mammals and is associated with celiac disease in humans. In mice, reovirus infects the intestine and disseminates systemically to cause serotype-specific patterns of disease in the brain. To identify receptors conferring reovirus serotype-dependent neuropathogenesis, we
Sookjin Moon et al.
The Journal of experimental medicine, 218(4) (2021-02-04)
Conventional CD4+ T cells are differentiated into CD4+CD8αα+ intraepithelial lymphocytes (IELs) in the intestine; however, the roles of intestinal epithelial cells (IECs) are poorly understood. Here, we showed that IECs expressed MHC class II (MHC II) and programmed death-ligand 1
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门