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质量水平
方案
≥95% (HPLC)
表单
lyophilized
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
溶解性
DMSO: 1 mg/mL
运输
ambient
储存温度
−20°C
一般描述
A substrate analog inhibitor of β-secretase (BACE) that completely blocks proteolytic activity in solubilized membrane fractions of BACE-transfected MDCK cells at a concentration of 5 µM.
A substrate analog inhibitor of β-secretase (BACE) that completely blocks the proteolytic activity (at 5 µM) in solubilized membrane fractions from BACE transfected MDCK cells.
生化/生理作用
Cell permeable: no
Effective concentration: 5 µM completely blocking the proteolytic activity of β-secretase (BACE) in solubilized membrane fractions from BACE transfected MDCK cells
Primary Target
BACE
BACE
Product does not compete with ATP.
Reversible: no
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
序列
H-Glu-Val-Asn-Statine-Val-Ala-Glu-Phe-NH₂
外形
Supplied as a trifluoroacetate salt.
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Capell, A., et al. 2002. J. Biol. Chem.277, 5637.
Tung, J.S., et al. 2002. J. Med. Chem.45, 259.
Tung, J.S., et al. 2002. J. Med. Chem.45, 259.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Molecular neurobiology, 56(12), 8603-8616 (2019-07-11)
The β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the main brain β-secretase responsible for the amyloidogenic processing of the amyloid precursor protein (APP). Previous studies have suggested that cerebrospinal fluid (CSF) β-secretase activity may be a candidate diagnostic
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