565777
γ-Secretase Inhibitor XVI
The γ-Secretase Inhibitor XVI, also referenced under CAS 208255-51-0, controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
别名:
γ-Secretase Inhibitor XVI, DAPM, N-[N-3,5-Difluorophenacetyl]-L-alanyl-S-phenylglycine Methyl Ester
产品名称
γ-Secretase Inhibitor XVI, The γ-Secretase Inhibitor XVI, also referenced under CAS 208255-51-0, controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
InChI key
XAPDRNSTUYCSQC-SGTLLEGYSA-N
InChI
1S/C20H20F2N2O4/c1-12(23-17(25)10-13-8-15(21)11-16(22)9-13)19(26)24-18(20(27)28-2)14-6-4-3-5-7-14/h3-9,11-12,18H,10H2,1-2H3,(H,23,25)(H,24,26)/t12-,18-/m0/s1
assay
≥97% (HPLC)
form
solid
potency
10 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 2 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell permeable: yes
Primary Target
γ-secretase Aβ₄₀ in 7PA2 cells
γ-secretase Aβ₄₀ in 7PA2 cells
Product does not compete with ATP.
Reversible: no
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell-permeable γ-secretase inhibitor that inhibits Aβ secretion (IC50 ~10 nM) by 7PA2 cells (CHO cell line stably transfected with APP751 containing V717F familial Alzheimer′s disease mutation) in a dose-dependent manner. Also exhibits anti-aggregation properties by selectively blocking Aβ dimer and trimer formation and subsequently preventing early Aβ oligomerization.
Other Notes
Walsh, D.M., et al. 2002. Nature 416, 535.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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