565750
γ-Secretase Inhibitor I
The γ-Secretase Inhibitor I controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
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别名:
γ-Secretase Inhibitor I, Z-LLNle-CHO
经验公式（希尔记法）:
C26H41N3O5
分子量:
475.62
UNSPSC代码:
12352200
NACRES:
NA.54
推荐产品
质量水平
检测方案
≥90% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
颜色
white
溶解性
DMSO: 10 mg/mL
50% acetic acid: soluble
运输
ambient
储存温度
−20°C
一般描述
Cell permeable. Inhibits γ-secretase, a protease that cleaves the Amyloid Precursor Protein (APP) to generate β-amyloid protein. Inhibition of this enzyme is believed to aid in the prevention of Alzheimer’s disease.
Inhibits γ-secretase, a protease that cleaves the amyloid precursor protein (APP). Inhibition of this enzyme is believed to aid in the prevention of Alzheimer′s disease.
生化/生理作用
Cell permeable: yes
Primary Target
γ-secretase
γ-secretase
Product does not compete with ATP.
Reversible: no
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
序列
Z-Leu-Leu-Nle-CHO (Nle = Norleucine)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Skovronsky, D.M., et al. 2000. Biochemistry 39, 810.
Hartmann, T., et al. 1997. Nat. Med. 3, 1016.
Hartmann, T., et al. 1997. Nat. Med. 3, 1016.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Shreoshi Sengupta et al.
eLife, 11 (2022-06-02)
Cancer stem cells (CSCs) alone can initiate and maintain tumors, but the function of non-cancer stem cells (non-CSCs) that form the tumor bulk remains poorly understood. Proteomic analysis showed a higher abundance of the extracellular matrix small leucine-rich proteoglycan fibromodulin
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