跳转至内容
Merck
CN

565749

β-Secretase Inhibitor II

The β-Secretase Inhibitor II, also referenced under CAS 263563-09-3, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

别名:

β-Secretase Inhibitor II, Z-VLL-CHO, N-Benzyloxycarbonyl-Val-Leu-leucinal

登录 查看组织和合同定价。

选择尺寸

关于此项目

经验公式（希尔记法）:
C25H39N3O5
化学文摘社编号:
263563-09-3
分子量:
461.59
MDL number:
MFCD03453567
UNSPSC Code:
12352200
NACRES:
NA.77

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

β-Secretase Inhibitor II, The β-Secretase Inhibitor II, also referenced under CAS 263563-09-3, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

InChI key

YHUAFMGVVANYBT-FKBYEOEOSA-N

InChI

1S/C25H39N3O5/c1-16(2)12-20(14-29)26-23(30)21(13-17(3)4)27-24(31)22(18(5)6)28-25(32)33-15-19-10-8-7-9-11-19/h7-11,14,16-18,20-22H,12-13,15H2,1-6H3,(H,26,30)(H,27,31)(H,28,32)/t20-,21-,22-/m0/s1

SMILES string

N([C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C=O)C(=O)OCc1ccccc1

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: yes
Primary Target
β-secretase
Product does not compete with ATP.
Reversible: yes
Target IC50: 700 nM and 2.5 µM against Aβtotal and Aβ1-42, respectively

Disclaimer

Toxicity: Standard Handling (A)

General description

A potent, cell-permeable, and reversible inhibitor of β-secretase that corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβtotal (IC50 = 700 nM) and Aβ1-42 (IC50 = 2.5 µM) in Chinese hamster ovary (CHO) cells stably transfected with wild-type APP751.

Other Notes

Abbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.
Z-Val-Leu-Leu-CHO

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Sarah Bui et al.
Methods in molecular biology (Clifton, N.J.), 2557, 453-493 (2022-12-14)
In this chapter, we provide a detailed guide for the application of commonly used small molecules to study Golgi structure and function in vitro. Furthermore, we have curated a concise, validated list of endomembrane markers typically used in downstream assays

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持