推荐产品
质量水平
检测方案
≥95% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
orange
溶解性
methanol: 1 mg/mL
DMSO: 50 mg/mL
运输
wet ice
储存温度
−20°C
InChI
1S/C27H30F3N3O3/c1-17(2)25-26(36)32-22(16-34)15-19-14-21(12-13-23(19)33(25)3)31-24(35)7-5-4-6-18-8-10-20(11-9-18)27(28,29)30/h4-14,17,22,25,34H,15-16H2,1-3H3,(H,31,35)(H,32,36)/b6-4+,7-5+/t22-,25-/m0/s1
InChI key
WOLVEMPZUIFSII-IHHOKICGSA-N
一般描述
一种细胞渗透性PKC激活剂(PKCα的Ki=11.9 nM),有效增强淀粉样前体蛋白(APP)的非淀粉样α加工,但缺乏任何促肿瘤活性。
一种细胞渗透性苯并内酰胺衍生的PKC激活剂(PKCα的Ki=11.9 nM),即使在100 nM时,也可有效增强人成纤维细胞AG06848中淀粉样前体蛋白(APP)的非淀粉样α-加工。显示肿瘤促进活性显着丧失。
生化/生理作用
主要靶标
PKC
PKC
产物不与ATP竞争。
可逆:否
细胞可渗透性:是
靶标Ki:对于活化PKC为11.9 nMα
包装
用惰性气体包装
警告
毒性:标准处理(A)
重悬
复溶后,等分并冷冻保存(-20°C)。贮备溶液在-20°C下可稳定保存至多6个月。
其他说明
Kozikowski, A.P., et al. 2003.J. Med. Chem.46, 364.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Methods in molecular biology (Clifton, N.J.), 2454, 327-349 (2021-04-01)
Pancreatic islet endocrine cells generated from patient-derived induced pluripotent stem cells represent a great strategy for both disease modeling and regenerative medicine. Nevertheless, these cells inherently miss the effects of the intricate network of systemic signals characterizing the living organisms.
Protocol development to further differentiate and transition stem cell-derived pancreatic progenitors from a monolayer into endocrine cells in suspension culture.
Scientific Reports, 13, 8877-8877 (2023)
Developmental cell, 58(9), 727-743 (2023-04-12)
Pancreatic islet cells derived from human pluripotent stem cells hold great promise for modeling and treating diabetes. Differences between stem-cell-derived and primary islets remain, but molecular insights to inform improvements are limited. Here, we acquire single-cell transcriptomes and accessible chromatin
Nature cell biology (2023-01-24)
Cell proliferation is fundamental for almost all stages of development and differentiation that require an increase in cell number. Although cell cycle phase has been associated with differentiation, the actual process of proliferation has not been considered as having a
Cell reports, 38(9), 110425-110425 (2022-03-03)
The HNF1αp291fsinsC truncation is the most common mutation associated with maturity-onset diabetes of the young 3 (MODY3). Although shown to impair HNF1α signaling, the mechanism by which HNF1αp291fsinsC causes MODY3 is not fully understood. Here we use MODY3 patient and
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