565730
Scriptaid
A relatively non-toxic, cell-permeable hydroxamic acid-containing histone deacetylase (HDAC) inhibitor.
登录查看公司和协议定价
所有图片(1)
Scriptaid, 6-(1,3-Dioxo-1 H,3 H-benzo[ de]isoquinolin-2-yl)-hexanoic Acid Hydroxyamide, CGK1026, HDAC Inhibitor XIII, 6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-hexanoic Acid Hydroxyamide, CGK1026, HDAC Inhibitor XIII
C18H18N2O4
推荐产品
质量水平
检测方案
≥95% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
off-white
溶解性
DMSO: 4 mg/mL
运输
ambient
储存温度
−20°C
InChI
1S/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)
InChI key
JTDYUFSDZATMKU-UHFFFAOYSA-N
一般描述
A relatively non-toxic hydroxamic acid-containing histone deacetylase (HDAC) inhibitor. Facilitates transcriptional activation (TGFβ/Smad4) in both stable and transient reporter assays in a concentration-dependent manner. Useful agent for transfection assays in reporter systems due to the lack of interference with the ability of reporter construct to measure positive activation of transcription factor in response to signal transduction stimulus. It causes over 100-fold increase in histone acetylation in PANC-1 cells at 2 µg/ml (6 µM). Reported to derepress hTERT by inhibiting the recruitment of HDAC into E2F-pocket protein complexes assembled on the hTERT promoter.
A relatively non-toxic, cell-permeable hydroxamic acid-containing histone deacetylase (HDAC) inhibitor. Facilitates transcriptional activation (TGFβ/Smad4) in both stable and transient receptor assays in a concentration-dependent manner. At ~2 µg/ml (6-8 µM) concentrations, results in a greater than 100-fold increase in histone acetylation in PANC-1 cells. Reported to derepress hTERT by inhibiting the recruitment of HDAC into E2F-pocket protein complexes assembled on the hTERT promoter.
生化/生理作用
Cell permeable: yes
Primary Target
HDAC
HDAC
Product does not compete with ATP.
Reversible: no
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Won, J., et al. 2004. Proc. Natl. Acad. Sci. USA101, 11328.
Su, G.H., et al. 2000. Cancer Res.60, 3137.
Su, G.H., et al. 2000. Cancer Res.60, 3137.
法律信息
Sold under license of U.S. Patent 6,544,957.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门