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Merck
CN
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主要文件

565610

Sigma-Aldrich

SC-560

A cell-permeable, highly potent and selective inhibitor of COX-1 (IC₅₀ = 9 nM).

别名:

SC-560, 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole

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About This Item

经验公式（希尔记法）:
C18H12F3IN2O
CAS号:
188817-13-2
分子量:
456.20
MDL编号:
MFCD02179214
UNSPSC代码:
12352200

质量水平

100

方案

≥98% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

off-white

溶解性

DMSO: 200 mg/mL

运输

ambient

储存温度

−20°C

InChI

1S/C17H12ClF3N2O/c1-24-14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3

InChI key

PQUGCKBLVKJMNT-UHFFFAOYSA-N

一般描述

A cell-permeable, highly potent and selective inhibitor of COX-1 (IC50 = 9 nM). Inhibits COX-2 only at higher concentrations (IC50 = 6.3 µM).
A cell-permeable, highly potent and selective inhibitor of cyclooxygenase-1 (COX-1; IC50 = 9 nM). Inhibits cyclooxygenase-2 (COX-2) only at higher concentrations (IC50 = 6.3 µM).

生化/生理作用

Cell permeable: yes
Primary Target
COX-1
Product does not compete with ATP.
Reversible: no
Target IC50: 9 nM against COX-1

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Ostrom, R.S., et al. 2001. Am. J. Physiol. Cell Physiol.281, C524.
Smith, C.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13313.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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