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COA分析证书/COQ

559396

SB 220025

Name: SB 220025
Brand: MM

A cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC₅₀ = 60 nM).

别名:

SB 220025, 5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole, p38 MAP Kinase Inhibitor XIV

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About This Item

经验公式（希尔记法）:

C₁₈H₁₉FN₆

CAS号:

165806-53-1

分子量:

338.38

UNSPSC代码:

12352202

NACRES:

NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

solid

效能

60 nM IC₅₀

制造商/商品名称

Calbiochem^®

储存条件

OK to freeze
desiccated (hygroscopic)
protect from light

颜色

white to pale yellow

溶解性

DMSO: 22 mg/mL

运输

ambient

储存温度

−20°C

InChI

1S/C18H19FN6/c19-13-3-1-12(2-4-13)16-17(15-7-10-22-18(20)24-15)25(11-23-16)14-5-8-21-9-6-14/h1-4,7,10-11,14,21H,5-6,8-9H2,(H2,20,22,24)

InChI key

VSPFURGQAYMVAN-UHFFFAOYSA-N

一般描述

A cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC₅₀ = 60 nM). Binds to an extended pocket in the active site of the enzyme. Exhibits over 2000-fold greater selectivity for p38 MAPK over ERK (p42/p44 MAP kinase), 500-fold over PKA, 50-fold over PKC, and >1000-fold over EGFR. Also acts as a potent inhibitor of angiogenesis and as an inhibitor of LPS-induced TNF-α production.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

A potent and specific inhibitor of human p38 mitogen-activated protein (MAP) kinase (IC₅₀ = 60 nM). Binds to an extended pocket in the active site of the enzyme. Exhibits >2500-fold greater selectivity for p38 MAPK over ERK (p42/p44 MAP kinase), 500-fold over PKA, 50-fold over PKC, and >1600-fold over EGFRK. Also acts as a potent inhibitor of angiogenesis and as an inhibitor of LPS-induced TNF-α production.

生化/生理作用

Primary Target
P38MAPK

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Jackson, J.R., et al. 1998. J. Pharmacol. Exp. Ther.284, 687.
Wang, Z., et al. 1998. Structure6, 1117.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 1

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