559395
SB 203580, Hydrochloride
SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells).
别名:
SB 203580, Hydrochloride, 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor XVI, Hydrochloride
登录查看公司和协议定价
所有图片(1)
About This Item
经验公式（希尔记法）:
C21H16FN3OS · xHCl
CAS号:
分子量:
377.43 (free base basis)
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
推荐产品
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
颜色
bright yellow
溶解性
water: 10 mg/mL
DMSO: soluble
运输
ambient
储存温度
−20°C
SMILES字符串
Fc1ccc(cc1)c2[nH]c(nc2c4ccncc4)c3ccc(cc3)[S](=O)C.Cl
InChI
1S/C21H16FN3OS.ClH/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15;/h2-13H,1H3,(H,24,25);1H
InChI key
WOSGGXINSLMASH-UHFFFAOYSA-N
一般描述
A water-soluble form of the potent MAP kinase inhibitor SB 203580 (Cat. No. 559389).
A water-soluble form of the potent MAP kinase inhibitor SB 203580 (Cat. No. 559389).
生化/生理作用
Cell permeable: yes
Primary Target
p38 MAP kinase
p38 MAP kinase
Product does not compete with ATP.
Reversible: no
Target IC50: 34 nM against p38 MAP kinase in vitro, 600 nM in cells; 50-100 nM against IL-1 and TNF-a production from LPS-stimulated human monocytes and the human monocyte cell line THP-1; 0.2-1.0 µM against platelet aggregation caused by collagen
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Merete Lund et al.
Biology of reproduction, 108(2), 258-268 (2022-10-11)
Angiogenesis within the ovarian follicle is an important component of ovulation. New capillary growth is initiated by the ovulatory surge of luteinizing hormone (LH), and angiogenesis is well underway at the time of follicle rupture. LH-stimulated follicular production of vascular
Silvia Fischer et al.
Journal of neuroinflammation, 18(1), 252-252 (2021-11-04)
Astrocytes participate in the local innate immune response of the central nervous system. In response to stress such as ischemia, activated cells release endogenous factors known as damage-associated molecular patterns (DAMPs). Self-extracellular RNA (eRNA) is such a ubiquitous alarm signal.
Alain P Gobert et al.
Cell reports, 33(11), 108510-108510 (2020-12-17)
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine.
Zhaojuan Yang et al.
Nature communications, 12(1), 4852-4852 (2021-08-13)
Oncogenic activation of KRAS and its surrogates is essential for tumour cell proliferation and survival, as well as for the development of protumourigenic microenvironments. Here, we show that the deubiquitinase USP12 is commonly downregulated in the KrasG12D-driven mouse lung tumour
Alice Prigent et al.
Journal of neurochemistry, 148(6), 746-760 (2018-12-28)
The protein alpha-synuclein whose expression is strongly implicated in Parkinson's disease (PD) is not only expressed in the CNS but also in the enteric nervous system (ENS). The growing body of evidence suggesting that gastrointestinal inflammation is involved in the
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门