557403
RNA 聚合酶 III抑制剂
RNA Polymerase III Inhibitor, CAS 577784-91-9, is a cell-permeable inhibitor of RNA Polymerase III (IC₅₀ = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively).
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所有图片(1)
别名:
RNA 聚合酶 III抑制剂, ML-60218，N-[1-（3-（5-氯-3-甲基苯并[b]噻吩-2-基-1-甲基-1H-吡唑-5-基）]-2-氯苯磺酰胺
经验公式（希尔记法）:
C19H15Cl2N3O2S2
推荐产品
质量水平
检测方案
≥95% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
off-white
溶解性
DMSO: 15 mg/mL
运输
ambient
储存温度
2-8°C
InChI
1S/C19H15Cl2N3O2S2/c1-11-13-9-12(20)7-8-16(13)27-19(11)15-10-18(24(2)22-15)23-28(25,26)17-6-4-3-5-14(17)21/h3-10,23H,1-2H3
InChI key
BVBDTTLISMIOJY-UHFFFAOYSA-N
一般描述
RNA聚合酶III(RNA Pol III)的细胞可渗透性抑制剂（对于人RNA Pol III的IC50=27 µM，对于酿酒酵母的RNA Pol III的IC50=32 µM）。通过阻止RNA Pol III介导的tRNA转录，来抑制酵母中的细胞生长。
一种对RNA聚合酶III具有广谱抑制活性的细胞可渗透性吲唑磺酰胺化合物(对于人和酿酒酵母RNA Pol III分别为IC50 = 27和32 µM）。通过阻止RNA Pol III介导的tRNA转录，来抑制酵母中的细胞生长。也可以25 mM的DMSO溶液（目录号557404）提供。
生化/生理作用
产物不与ATP竞争。
可逆：否
抗RNA聚合酶III的主要靶标
活性
活性
细胞可渗透性：是
靶标IC50：对于人为27M，对于酿酒酵母RNA Pol III为32 µM
包装
用惰性气体包装
警告
毒性：致癌/致畸（D）
制备说明
可能需要稍微加热才能完全溶解。
重悬
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
其他说明
Wu, L., et al. 2003.Euk.Cell2, 256.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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