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质量水平
检测方案
≥95% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 50 mg/mL
ethanol: soluble
运输
ambient
储存温度
−20°C
一般描述
一种细胞渗透性乙酰肼，剂量依赖性地抑制HepG2和其他细胞中缺氧诱导的线粒体ROS生成（≤ 10 µM），并抑制HUVEC、HeLa和HCT15培养物中的细胞生长（≤ 50 µM）。在≤10 µM时，该化合物在体外强烈抑制VGFR诱导的HUVEC管形成和侵袭活性，而无明显毒性。它还显示在鸡胚CAM试验中阻碍毛细血管形成，而体内没有任何血栓形成和出血的迹象。此外，它呈剂量依赖性地减弱HIF-1α及其靶基因VEGF（0–10 µM）的表达水平。
一种细胞渗透性乙酰肼，剂量依赖性地抑制HepG2和其他细胞中缺氧诱导的线粒体ROS生成（≤10 µM），并抑制HUVEC、HeLa和HCT15培养物中的细胞生长（≤50 µM）。在≤10 µM时，该化合物在体外强烈抑制VGFR诱导的HUVEC管形成和侵袭活性，而无明显毒性。它还显示在鸡胚CAM试验中阻碍毛细血管形成，而体内没有任何血栓形成和出血的迹象。此外，它呈剂量依赖性地减弱HIF-1α及其靶基因VEGF（0–10 µM）的表达水平。
包装
用惰性气体包装
警告
毒性：标准处理（A）
重悬
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
其他说明
Kim, K.H., et al. 2011.Biochem.Biophys.Res. Commun.404, 541.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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