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Merck
CN

557303

利福平

≥97% (HPLC), powder (or crystals), RNA polymerase inhibitor, Calbiochem®

别名:

利福平

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关于此项目

经验公式（希尔记法）:
C43H58N4O12
化学文摘社编号:
13292-46-1
分子量:
822.94
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00151389

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产品名称

利福平, Antibiotic that specifically inhibits DNA-dependent RNA polymerase in bacteria by forming an inactive complex.

SMILES string

N5(CCN(CC5)C)\N=C\c1c2c(c3c(c4c(c(c3O)C)O[C@](O\C=C\[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]([C@H](\C=C\C=C(/C(=O)N2)\C)C)O)C)O)C)OC(=O)C)C)OC)(C4=O)C)c1O)O

InChI

1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1

InChI key

JQXXHWHPUNPDRT-WLSIYKJHSA-N

assay

~97-102% (by Assay)

form

powder (or crystals)

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

red-brown

shipped in

ambient

storage temp.

−20°C

Quality Level

100

相关类别

Biochem/physiol Actions

细菌中的主要靶标
DNA依赖性RNA聚合酶

Disclaimer

毒性：有害&致癌/致畸性（E）

General description

通过与RNA聚合酶形成非活性复合物，特异性抑制DNA依赖性细菌RNA聚合酶的抗生素。不影响哺乳动物RNA聚合酶。通过阻止初始转录复合物进入伸长模式来抑制转录。

Other Notes

Jin, D.J. and Turnbough, Jr., C.L.1994.J. Mol.Biol. 236, 72.
Levin, M.E. and Hatfull, G.F.1993.Mol.Microbiol.8, 277.
Wehrli, W., et al. 1968.Proc.Natl.Acad.Sci. USA61, 667.

Preparation Note

复溶后，等分并冷冻保存（-20°C）。DMSO贮备溶液可在-20°C最长稳定2个月。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Morten Kals et al.
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We describe a phenotypic antibiotic susceptibility testing (AST) method that can provide an eightfold speed-up in turnaround time compared with the current clinical standard by leveraging advances in microscopy and single-cell imaging. A newly developed growth plate containing 96 agarose
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Journal of biomedical research, 37(6), 431-447 (2023-11-22)
cis-Diamminedichloroplatinum (CDDP) is widely used for the treatment of various solid cancers. Here we reported that CDDP increased the expression and enzymatic activities of carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2), along with the upregulation of pregnane X receptor (PXR)
Lama Shamseddine et al.
iScience, 26(9), 107563-107563 (2023-09-04)
In a scenario where the discovery of new molecules to fight antibiotic resistance is a public health concern, ribosomally synthesized and post-translationally modified peptides constitute a promising alternative. In this context, the Gram-positive human gut symbiont Ruminococcus gnavus E1 produces

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