product name
利福平, Antibiotic that specifically inhibits DNA-dependent RNA polymerase in bacteria by forming an inactive complex.
质量水平
检测方案
~97-102% (by Assay)
形式
powder (or crystals)
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
red-brown
运输
ambient
储存温度
−20°C
InChI
1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1
InChI key
JQXXHWHPUNPDRT-WLSIYKJHSA-N
一般描述
通过与RNA聚合酶形成非活性复合物，特异性抑制DNA依赖性细菌RNA聚合酶的抗生素。不影响哺乳动物RNA聚合酶。通过阻止初始转录复合物进入伸长模式来抑制转录。
通过形成非活性复合物，在细菌中特异性抑制DNA依赖性RNA聚合酶的抗生素。不影响哺乳动物RNA聚合酶。通过阻止初始转录复合物进入伸长模式来抑制转录。
生化/生理作用
细菌中的主要靶标
DNA依赖性RNA聚合酶
DNA依赖性RNA聚合酶
警告
毒性：有害&致癌/致畸性（E）
重悬
复溶后，等分并冷冻保存（-20°C）。DMSO贮备溶液可在-20°C最长稳定2个月。
其他说明
Jin, D.J. and Turnbough, Jr., C.L.1994.J. Mol.Biol. 236, 72.
Levin, M.E. and Hatfull, G.F.1993.Mol.Microbiol.8, 277.
Wehrli, W., et al. 1968.Proc.Natl.Acad.Sci. USA61, 667.
Levin, M.E. and Hatfull, G.F.1993.Mol.Microbiol.8, 277.
Wehrli, W., et al. 1968.Proc.Natl.Acad.Sci. USA61, 667.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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