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Merck
CN
所有图片(1)

文件

554720

Millipore

反式-维甲酸

Potent modulator of growth and differentiation. Inhibits melanocyte adhesion, motility, and growth.

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别名:
反式-维甲酸, 维甲酸，ATRA，维生素A酸
经验公式（希尔记法）:
C20H28O2
CAS号:
302-79-4
分子量:
300.44
MDL编号:
MFCD00001551
UNSPSC代码:
12352106
NACRES:
NA.21

质量水平

100

检测方案

≥95% (by assay)

形式

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)
protect from light

颜色

yellow

溶解性

DMSO: 25 mg/mL

运输

ambient

储存温度

2-8°C

InChI

1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+

InChI key

SHGAZHPCJJPHSC-YCNIQYBTSA-N

相关类别

一般描述

生长和分化的有效调节剂。通过与直接调节基因表达的核视黄酸受体（RAR）结合发挥作用。抑制黑素细胞粘附、运动和生长。具有角膜溶解活性。诱导神经源性肿瘤细胞分化。诱导急性早幼粒细胞癌细胞凋亡。
生长和分化的有效调节剂。通过与直接调节基因表达的核视黄酸受体（RAR）结合发挥作用。抑制黑素细胞粘附、运动和生长。具有角膜溶解活性。诱导神经源性肿瘤细胞分化。诱导急性早幼粒细胞癌细胞凋亡。避免空气。

应用


  • All-trans-retinoic acid modulates glycolysis via H19 and telomerase: the role of mir-let-7a in estrogen receptor-positive breast cancer cells.: This research reveals how all-trans-retinoic acid influences glycolysis in breast cancer cells by modulating H19 and telomerase, demonstrating its potential in breast cancer therapy (El Habre et al., 2024).

  • Retinoic acid tiers mitochondrial metabolism to Sertoli Cell-Mediated efferocytosis via a non-RAR-dependent mechanism.: The study explores the role of retinoic acid in linking mitochondrial metabolism to efferocytosis in Sertoli cells, providing insights into its non-RAR-dependent mechanisms and potential applications in reproductive biology (Wu et al., 2024).

  • Combined treatment of All-trans retinoic acid with Tamoxifen suppresses ovarian cancer.: This article discusses the synergistic effects of combining all-trans-retinoic acid with tamoxifen in suppressing ovarian cancer, highlighting a promising therapeutic strategy for ovarian cancer patients (Xu et al., 2024).

包装

用惰性气体包装

警告

毒性：有害 & 致癌/致畸性（E）

重悬

复溶后冷藏（4°C）。DMSO贮备溶液在4°C下可稳定保存最多2年。

其他说明

Tosi, P., et al. 1994.Leuk.Lymphoma14, 503.
Clagett-Dame, M., et al. 1993.Arch.Biochem.Biophys.300, 684.
Labbaye, C., et al. 1993.Blood81, 475.
Sakashita, A., et al. 1993.Blood81, 1009.
Situ, R., et al. 1993.Dermatology186, 38.
Tini, M., et al. 1993.Genes Develop.7, 295.
Leid, M., et al. 1992.Trends Biochem.Sci.17, 427.
Sharpe, C.R.1991.Neuron7, 239.
Thaller, C. and Eichele, G. 1990.Nature345, 815.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

警示用语：

Danger

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - Skin Irrit. 2

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Natalia Moskal et al.
Nature communications, 11(1), 88-88 (2020-01-05)
The accumulation of damaged mitochondria causes the death of dopaminergic neurons. The Parkin-mediated mitophagy pathway functions to remove these mitochondria from cells. Targeting this pathway represents a therapeutic strategy for several neurodegenerative diseases, most notably Parkinson's disease. We describe a

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