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质量水平
方案
≥93% (HPLC)
表单
liquid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
运输
ambient
储存温度
−20°C
SMILES字符串
CC1=CC=C(NC(C2=CC(OCC3=C(C)ON=C3C)=CC=C2)=O)C=C1S(N)(=O)=O
InChI
1S/C20H21N3O5S/c1-12-7-8-16(10-19(12)29(21,25)26)22-20(24)15-5-4-6-17(9-15)27-11-18-13(2)23-28-14(18)3/h4-10H,11H2,1-3H3,(H,22,24)(H2,21,25,26)
InChI key
OZZQJOAJXMUXCO-UHFFFAOYSA-N
一般描述
A cell-permeable isoxazolyl-benzamide compound that is more effective than NSC23766 (Cat. Nos. 553502 & 553508) in inhibiting PDGF-BB- (Cat. No. 521225) induced cellular Rac1 activation (45.8% vs 11.1% inhibition by 4 h pretreatment of the respective compound at 50 µM) in serum-starved SMCs (human aortic smooth muscle cells) by interfering Rac1-Tiam1 interaction, while exhibiting no effect toward cellular Cdc42 and RhoA activation or Rac1 interaction to its effector Pak1. Shown to effectively prevent PDGF-BB-induced membrane ruffling and lamellipodia formation in serum-starved 3T3 cells (4 h pretreatment at 25 µM). The solid form of this compound (Cat. No. 553511) is also available.
包装
Packaged under inert gas
警告
Toxicity: Irritant (B)
外形
A 100 mM (10 mg/241 µl) solution of Rac1 Inhibitor II, Z62954982 (Cat. No. 553511) in DMSO
重悬
Following initial thaw, aliquot and freeze (-20°C).
其他说明
Ferri, N., et al. 2009. J. Med. Chem.52, 4087.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
188.6 °F - closed cup - (refers to pure substance)
闪点(°C)
87 °C - closed cup - (refers to pure substance)
Chitra Basu et al.
Scientific reports, 14(1), 9991-9991 (2024-05-02)
Endothelial cells (ECs) have essential roles in cardiac tissue repair after myocardial infarction (MI). To establish stage-specific and long-term effects of the ischemic injury on cardiac ECs, we analyzed their transcriptome at landmark time points after MI in mice. We
Kasia Kozyrska et al.
Science (New York, N.Y.), 375(6581), eabl8876-eabl8876 (2022-02-11)
Epithelial cells migrate across wounds to repair injured tissue. Leader cells at the front of migrating sheets often drive this process. However, it is unclear how leaders emerge from an apparently homogeneous epithelial cell population. We characterized leaders emerging from
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