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Merck
CN
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主要文件

540500

Sigma-Aldrich

Purvalanol A

A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases.

别名:

Purvalanol A, 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine

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About This Item

经验公式（希尔记法）:
C19H25ClN6O
CAS号:
212844-53-6
分子量:
388.89
MDL编号:
MFCD02179211
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

100

方案

≥97% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze

颜色

off-white

溶解性

DMSO: 100 mg/mL

运输

ambient

储存温度

−20°C

SMILES字符串

Clc1cc(ccc1)Nc2nc(nc3[n](cnc32)C(C)C)N[C@@H](CO)C(C)C

InChI

1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1

InChI key

PMXCMJLOPOFPBT-HNNXBMFYSA-N

一般描述

A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks; IC50 = 4 nM for Cdc2-cyclin B; IC50 = 70 nM for Cdk2-cyclin A; IC50 = 35 nM for Cdk2-cyclin E; and IC50 = 75 nM for Cdk5-p35).
A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks; IC50 = 4 nM for Cdc2/cyclin B; IC50 = 70 nM for Cdk2/cyclin A; IC50 = 35 nM for Cdk2/cyclin E; and IC50 = 75 nM for Cdk5/p35).

生化/生理作用

Cell permeable: yes
Primary Target
Cdc2/cyclin B
Product does not compete with ATP.
Reversible: yes
Target IC50: 4 nM for Cdc2/cyclin B; 70 nM for Cdk2/cyclin A; 35 nM for Cdk2/cyclin E; 75 nM for Cdk5/p35

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following initial thaw, aliquot and freeze (-20°C).

其他说明

Gray, N.S., et al. 1998. Science 281, 533.

法律信息

Sold under license of U.S. Patents 6,617,331 and 6,803,371.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

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