推荐产品
质量水平
检测方案
≥98% (TLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated
颜色
white to off-white
溶解性
methanol: 20 mg/mL
water: 50 mg/mL
运输
ambient
储存温度
−20°C
InChI
1S/C22H29N7O5.2ClH/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12;;/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32);2*1H/t14-,15+,16?,18+,22+;;/m0../s1
InChI key
MKSVFGKWZLUTTO-USYAMCSGSA-N
一般描述
原核和真核蛋白质合成抑制剂。类似于氨酰tRNA的氨酰腺苷酸末端相似的核苷，与大核糖体亚单位的“A位点”竞争结合。其掺入生长中的多肽，导致链延伸终止和新生多肽基嘌呤霉素的释放。用于选择表达转染pac基因（白黑链霉菌）的哺乳动物细胞系，其产物嘌呤霉素乙酰转移酶通过乙酰化使药物失活。诱导胸腺细胞和HL-60白血病细胞内DNA断裂。与放线菌酮一样，嘌呤霉素也被用作多种细胞分析中的通用蛋白质合成抑制剂。
嘌呤霉素二盐酸盐，CAS 58-58-2，是一种氨基核苷抗生素，通过阻断翻译步骤抑制蛋白质合成，并引起新生多肽链过早释放。
蛋白质合成抑制剂。通过导致新生多肽链过早释放来抑制翻译。诱导胸腺细胞和HL-60白血病细胞内DNA断裂。
生化/生理作用
首要靶标
蛋白质合成
蛋白质合成
警告
毒性：有害（C）
重悬
复溶后，通过0.22 µm孔径的过滤器过滤灭菌，等分并冷冻（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
其他说明
Chow, S.C., et al. 1995.Exp.Cell Res. 216, 149.
Constam, D.B., et al. 1995.J. Biol. Chem.270, 26931.
Wirth, M., et al. 1994.J. Virol.68, 566.
Claeyssens, S., et al. 1993.FEBS Lett.315, 7.
Hechler, U., et al. 1993.Biochem.Biophys.Res. Commun.194, 1305.
Kaufman, S.H., et al. 1993.Cancer Res.53, 3976.
de la Luna, S. and Ortín, J. 1992.Methods Enzymol.216, 376.
Kalpaxis, D.L. and Drainas, D. 1992.Arch.Biochem.Biophys.300, 629.
Shipston, M.J. and Antoni, F.A.1992.Biochem.Biophys.Res. Commun.189, 1382.
Constam, D.B., et al. 1995.J. Biol. Chem.270, 26931.
Wirth, M., et al. 1994.J. Virol.68, 566.
Claeyssens, S., et al. 1993.FEBS Lett.315, 7.
Hechler, U., et al. 1993.Biochem.Biophys.Res. Commun.194, 1305.
Kaufman, S.H., et al. 1993.Cancer Res.53, 3976.
de la Luna, S. and Ortín, J. 1992.Methods Enzymol.216, 376.
Kalpaxis, D.L. and Drainas, D. 1992.Arch.Biochem.Biophys.300, 629.
Shipston, M.J. and Antoni, F.A.1992.Biochem.Biophys.Res. Commun.189, 1382.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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