推荐产品
产品名称
嘌吗啡胺, A cell-permeable activator of Hedgehog signaling that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC₅₀ = 1 µM).
方案
≥98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
off-white
溶解性
DMSO: 200 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
N7(CCOCC7)c1ccc(cc1)Nc2nc(nc5[n](cnc52)C6CCCCC6)Oc3c4c(ccc3)cccc4
InChI
1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)
InChI key
FYBHCRQFSFYWPY-UHFFFAOYSA-N
一般描述
一种刺猬信号的细胞渗透激活剂，可诱导多能间充质祖细胞C3H10T1/2（EC₅₀=1 µM）的成骨细胞分化。
一种细胞可渗透的2,6,9-三取代嘌呤化合物，可诱导多能间充质祖细胞C3H10T1/2（EC50=1 µM）和谱系固定的前成骨细胞MC3T3-E1的成骨细胞分化。它的作用可以与BMP-4（骨形态发生蛋白-4）的作用协同，并且已显示即使在前脂肪细胞和成肌细胞中也能诱导转分化。据报道通过激活刺猬信号通路诱导成骨。也可提供50 mM (5 mg/192 µl)2,6,9-三元取代嘌呤（目录号540223）在DMSO中的溶液。
请注意，由于水含量的变化，该化合物的分子量是因批次特异性的。
请注意，由于水含量的变化，该化合物的分子量是因批次特异性的。
一种细胞渗透性嘌呤化合物，可在C3H10T1/2多能间充质祖细胞（EC50 = 1 µM）和MC3T3-E1谱系中诱导成骨细胞分化。还显示在前脂肪细胞和成肌细胞中诱导转分化。据报道，其作用与骨形态发生蛋白-4（BMP-4）具有协同作用。据报道通过激活刺猬信号通路诱导成骨。
生化/生理作用
EC50 = 1 µM，用于诱导多能间充质祖细胞C3H10T1/2的成骨细胞分化
主靶
刺猬信号通路的激活
刺猬信号通路的激活
产物不与ATP竞争。
细胞可渗透性：是
警告
毒性：有害（C）
重悬
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险声明
危险分类
Muta. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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