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Merck
CN
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文件

539741

Sigma-Aldrich

PTP1B抑制剂

PTP1B Inhibitor, CAS 765317-72-4, is a cell-permeable, selective, reversible and non-competitive allosteric inhibitor of PTP1B (IC₅₀ = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively).

别名:

PTP1B抑制剂

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About This Item

经验公式（希尔记法）:
C26H19Br2N3O7S3
CAS号:
765317-72-4
分子量:
741.45
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

100

检测方案

≥95% (HPLC)

形式

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

white

溶解性

DMSO: 100 mg/mL
ethanol: 5 mg/mL

运输

wet ice

储存温度

−20°C

InChI

1S/C26H19Br2N3O7S3/c1-2-21-23(24(32)14-11-19(27)25(33)20(28)12-14)18-8-7-17(13-22(18)38-21)41(36,37)30-15-3-5-16(6-4-15)40(34,35)31-26-29-9-10-39-26/h3-13,30,33H,2H2,1H3,(H,29,31)

InChI key

SXKBTDJJEQQEGE-UHFFFAOYSA-N

一般描述

一种PTP1B的细胞渗透性、选择性、可逆和非竞争性变构抑制剂（PTP1B403和PTP1B298的IC50 分别为4 µM和8 µM）。结合到远离催化口袋的新位点，并通过阻止WPD环闭合来抑制PTP1B活性。也可提供InSolution格式（目录号539749。

生化/生理作用

主要靶标
PTP1B403
产物不与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：对于PTP1B403和PTP1B298分别为4 µM和8 µM。

包装

用惰性气体包装

警告

毒性：标准处理（A）

重悬

复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多6个月。

其他说明

Wiesmann, C., et al. 2004.Nat. Struct.Mol.Biol.11, 730.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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