539690
Protein Synthesis Initiation Inhibitor, NSC 119889
The Protein Synthesis Initiation Inhibitor, NSC 119889 blocks 5′-mediated/cap-dependent initiation of protein synthesis. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
别名:
Protein Synthesis Initiation Inhibitor, NSC 119889, 3,4,5,6-Tetrabromofluorescein
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About This Item
经验公式（希尔记法）:
C20H8Br4O5
分子量:
647.89
UNSPSC代码:
12352202
NACRES:
NA.77
质量水平
检测方案
≥95% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
light brown
溶解性
DMSO: 200 mg/mL
methanol: soluble
运输
ambient
储存温度
2-8°C
一般描述
A cell-permeable, xanthenyl compound that prevents mRNA-ribosome interaction and inhibits 5’-mediated/cap-dependent initiation of protein synthesis (>95% inhibition at 50 µM in in vitro translation assays using Krebs, rabbit reticulocyte, or E. coli S30 extract).
A cell-permeable, xanthenyl compound that prevents mRNA-ribosome interaction and inhibits 5′-mediated/cap-dependent initiation of protein synthesis (>95% inhibition at 50 µM in in vitro translation assays using Krebs, rabbit reticulocyte, or E. coli S30 extract).
生化/生理作用
Cell permeable: yes
Primary Target
human arginine methyl transferase
human arginine methyl transferase
Product does not compete with ATP.
Reversible: no
Target IC50: 1.41 µM against human arginine methyl transferase
警告
Toxicity: Irritant (B)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Novac, O., et al. 2004. Nucleic Acids Res.32, 902.
Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol.129, 437.
Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol.129, 437.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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