Serine/Threonine Kinase Inhibitor Set

Cell permeable: yes

Primary Target
PKA

Secondary Target
PKC, MLCK, Cam kinase II, PKG

Toxicity: Multiple Toxicity Values, refer to MSDS (O)

A convenient set that offers several highly selective serine/threonine kinase inhibitors. Kinases play an important role in numerous signaling cascades. Highly selective protein kinase inhibitors are useful for dissecting these cascades to determine which specific kinases are involved in producing particular biological effects. The Serine/Threonine Kinase Inhibitor Set contains the following highly selective serine/ threonine kinase inhibitors in one convenient set:



• Bisindolylmaleimide I (Cat. No. 203290), 250 µg

• H-89, Dihydrochloride (Cat. No. 371963), 1 mg

• KN-93 (Cat. No. 422708), 1 mg

• ML-7 (Cat. No. 475880), 1 mg

• Protein Kinase G Inhibitor (Cat. No. 370654), 1 mg

• Staurosporine (Cat. No. 569397), 100 µg

Martiny, G., et al. 1993. J. Biol. Chem.268, 9194.
Toullec, D., et al. 1991. J. Biol. Chem.266, 15771.
Chijiwa, T., et al. 1990. J. Biol. Chem.265, 5267.
Simu, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 968.
Saitoh, M., et al. J. Biol. Chem.262, 7796.
Glass, D.B., et al. 1983. Biochem. J.213, 159.
Seynaeve, C.M., et al. 1994. Mol. Pharmacol.45, 1207.
Meyer, T., et al. 1989. Int. J. Cancer43, 851.

Following reconstitution, aliquot and freeze (-20°C). Stock solutions of each inhibitor are stable for up to 3 months at -20°C.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany