产品名称
Anti-PP2A/A (7-19) (PR65) Rabbit pAb, liquid, Calbiochem®
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
liquid
contains
≤0.1% sodium azide as preservative
species reactivity (predicted by homology)
mammals
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
isotype
IgG
shipped in
wet ice
storage temp.
−70°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PTPA(5524)
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Application
Immunoblotting (1:500)
Immunocytochemistry (1:500)
Immunocytochemistry (1:500)
Disclaimer
Toxicity: Standard Handling (A)
General description
Immunoaffinity purified rabbit polyclonal antibody. Recognizes the ~65 kDa α- and β-isoforms of the A(PR65) regulatory subunit of PP2A.
Immunogen
Mammalian
a synthetic peptide (DDSLYPIAVLIDE) corresponding to amino acids 7-19 of the mammalian PP2A/A regulatory subunit, conjugated to KLH
Other Notes
Cross-reacts with PR65 from most mammalian species, including human, rat, and mouse. Exhibits minor cross-reactivity with tubulin in whole brain homogenates. Variables associated with assay conditions will dictate the proper working dilution.
Physical form
In 10 mM Tris-HCl, 3 mM glycine, pH 7.5.
Preparation Note
Following initial thaw, aliquot and freeze (-70°C).
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Sean C Little et al.
Science signaling, 8(386), ra72-ra72 (2015-07-23)
Protein phosphatase 2A (PP2A) is a serine/threonine-selective holoenzyme composed of a catalytic, scaffolding, and regulatory subunit. In the heart, PP2A activity is requisite for cardiac excitation-contraction coupling and central in adrenergic signaling. We found that mice deficient in the PP2A
Sean T DeGrande et al.
The Journal of biological chemistry, 288(2), 1032-1046 (2012-12-04)
Kinase/phosphatase balance governs cardiac excitability in health and disease. Although detailed mechanisms for cardiac kinase regulation are established, far less is known regarding cardiac protein phosphatase 2A (PP2A) regulation. This is largely due to the complexity of the PP2A holoenzyme
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