推荐产品
生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
liquid
包含
≤0.1% sodium azide as preservative
种属反应性（根据同源性预测）
mammals
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
avoid repeated freeze/thaw cycles
同位素/亚型
IgG
运输
wet ice
储存温度
−70°C
靶向翻译后修饰
unmodified
基因信息
human ... PTPA(5524)
一般描述
Immunoaffinity purified rabbit polyclonal antibody. Recognizes the ~65 kDa α- and β-isoforms of the A(PR65) regulatory subunit of PP2A.
免疫原
Mammalian
a synthetic peptide (DDSLYPIAVLIDE) corresponding to amino acids 7-19 of the mammalian PP2A/A regulatory subunit, conjugated to KLH
应用
Immunoblotting (1:500)
Immunocytochemistry (1:500)
Immunocytochemistry (1:500)
警告
Toxicity: Standard Handling (A)
外形
In 10 mM Tris-HCl, 3 mM glycine, pH 7.5.
重悬
Following initial thaw, aliquot and freeze (-70°C).
其他说明
Cross-reacts with PR65 from most mammalian species, including human, rat, and mouse. Exhibits minor cross-reactivity with tubulin in whole brain homogenates. Variables associated with assay conditions will dictate the proper working dilution.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Sean C Little et al.
Science signaling, 8(386), ra72-ra72 (2015-07-23)
Protein phosphatase 2A (PP2A) is a serine/threonine-selective holoenzyme composed of a catalytic, scaffolding, and regulatory subunit. In the heart, PP2A activity is requisite for cardiac excitation-contraction coupling and central in adrenergic signaling. We found that mice deficient in the PP2A
Sean T DeGrande et al.
The Journal of biological chemistry, 288(2), 1032-1046 (2012-12-04)
Kinase/phosphatase balance governs cardiac excitability in health and disease. Although detailed mechanisms for cardiac kinase regulation are established, far less is known regarding cardiac protein phosphatase 2A (PP2A) regulation. This is largely due to the complexity of the PP2A holoenzyme
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