539162
Proteasome Inhibitor II
The Proteasome Inhibitor II controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
别名:
Proteasome Inhibitor II, (Benzyloxycarbonyl)-Leu-Leu-phenylalaninal, Z-LLF-CHO
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About This Item
经验公式（希尔记法）:
C29H39N3O5
分子量:
509.64
UNSPSC代码:
12352200
NACRES:
NA.77
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质量水平
方案
≥95% (HPLC)
表单
lyophilized solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated
颜色
white
溶解性
DMSO: 5 mg/mL
运输
ambient
储存温度
−20°C
一般描述
A potent, cell-permeable, and reversible proteasome inhibitor. Inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (MPC; Ki = 460 nM). Does not inhibit the peptidyl-glutamyl peptide hydrolyzing activity of MPC even at concentrations of 200 µM. Also blocks the decay of IκB-α and IκB-β proteins in exponentially growing WEHI 231 cells.
生化/生理作用
Cell permeable: yes
Primary Target
MPC
MPC
Product does not compete with ATP.
Reversible: yes
Target Ki: 460 nM against the pituitary multicatalytic proteinase complex (MPC)
警告
Toxicity: Standard Handling (A)
序列
Z-Leu-Leu-Phe-CHO
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.
其他说明
Schauer, S.L., et al. 1998. J. Immunol. 160, 4398.
Orlowski, M., et al. 1997. Biochemistry 36, 13946.
Orlowski, M., et al. 1993. Biochemistry 32, 1563.
Orlowski, M., et al. 1997. Biochemistry 36, 13946.
Orlowski, M., et al. 1993. Biochemistry 32, 1563.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
相关内容
Select different protease inhibitor types based on your needs to prevent protein degradation during isolation and characterization and safeguard proteins in sample prep.
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