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Merck
CN
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539160

Sigma-Aldrich

Proteasome Inhibitor I

The Proteasome Inhibitor I controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

别名:

Proteasome Inhibitor I, PSI

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选择尺寸

25 G
CN¥927.94

CN¥927.94

国内现货，预计发货时间April 27, 2025详情

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25 G
CN¥927.94

About This Item

经验公式（希尔记法）:
C32H50N4O8
分子量:
618.76
UNSPSC代码:
12352202
NACRES:
NA.77

CN¥927.94

国内现货，预计发货时间April 27, 2025详情

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质量水平

100

方案

≥90% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze

颜色

white

溶解性

DMSO: 30 mg/mL
ethanol: 30 mg/mL
methanol: soluble

运输

ambient

储存温度

−20°C

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1 of 4

此商品
864774959886473
(−)-松油烯-4-醇 ≥95.0% (sum of enantiomers, GC)

11584

(−)-松油烯-4-醇

(+)-萜品烯-4-醇 analytical standard

86477

(+)-萜品烯-4-醇

(−)-松油烯-4-醇 analytical standard

49598

(−)-松油烯-4-醇

α-松油烯 ≥95.0% (GC)

86473

α-松油烯

assay

≥95.0% (sum of enantiomers, GC)

assay

≥98.0% (sum of enantiomers, GC)

assay

≥95.0% (sum of enantiomers, GC)

assay

≥95.0% (GC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

density

0.934 g/mL at 20 °C

density

0.933 g/mL at 20 °C (lit.)

density

0.934 g/mL at 20 °C

density

0.837 g/mL at 25 °C (lit.)

refractive index

n20/D 1.479

refractive index

n20/D 1.479

refractive index

-

refractive index

n20/D 1.478 (lit.)

optical activity

[α]20/D -25±6°, neat

optical activity

-

optical activity

[α]/D -25±6°, neat

optical activity

-

optical purity

enantiomeric ratio: ~2:1

optical purity

enantiomeric ratio: ~2:1

optical purity

enantiomeric ratio: ~2:1

optical purity

-

一般描述

A cell-permeable, reversible inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells. Causes the accumulation of ubiquitinated proteins in neuronal cells. Prevents the activation of NF-κB in response to TNF-α and Okadaic Acid (Cat. No. 495604) through inhibition of IκB-α degradation. A 50 mM (5 mg/162 µl) solution of Proteasome Inhibitor I (Cat. No. 539161) in DMSO is also available.
Cell-permeable inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells. Causes the accumulation of ubiquitinylated proteins in neuronal cells. Prevents NF-κB activation in response to TNFα and okadaic acid through inhibition of IκB-α degradation, thereby interfering with induction of iNOS in macrophages.

生化/生理作用

Cell permeable: yes
Primary Target
Chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells
Product does not compete with ATP.
Reversible: yes

警告

Toxicity: Standard Handling (A)

序列

Z-Ile-Glu(OtBu)-Ala-Leu-CHO

重悬

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.

其他说明

Griscavage, J.M., et al. 1996. Proc. Natl. Acad. Sci. USA93, 3308.
Mori, S., et al. 1995. J. Biol. Chem.270, 29447.
Figueiredo-Pereira, M.E., et al. 1994. J. Neurochem. 63, 1578.
Traenckner, E.B., et al. 1994. EMBO J. 13, 5433.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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