537076
前蛋白转化酶抑制剂
The Proprotein Convertase Inhibitor controls the biological activity of Proprotein Convertase. This small molecule/inhibitor is primarily used for Cell Signaling applications.
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所有图片(1)
别名:
前蛋白转化酶抑制剂, PACE4抑制剂，Furin-样蛋白质前体加工酶抑制剂，Furin抑制剂III，PC1/3抑制剂，PC4抑制剂，PC5/6抑制剂
经验公式（希尔记法）:
C35H55N15O4
分子量:
749.91
UNSPSC代码:
12352200
推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
solid
效能
16 pM Ki
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 100 mg/mL
运输
ambient
储存温度
−20°C
一般描述
一种细胞渗透性三肽衍生物，含有Arg-X-Arg激酶，可作为的强效可逆furin抑制剂(Ki = 16 pM)。还显示出以几乎相似的效力，抑制其他几种前蛋白转化酶，如PC1/3、PC4、PAEC4、PC5/6，但不会以任何显著方式影响PC2、PC7和胰蛋白酶样丝氨酸蛋白酶。作为纤溶酶的极弱抑制剂(Ki=7.3 µM)。在细胞中表现出较大的稳定性。显示出以剂量依赖性方式阻断血凝素裂解（1 µM时为40%）和禽瘟病毒（FPV）的传播。即使在高浓度（25-50 µM）下也表现出最小的毒性，并保护人类表皮样癌（HEp-2）细胞免受志贺氏毒素的毒性作用
生化/生理作用
主靶
Furin、PAEC4、PC1/3、PC4和PC5/6
Furin、PAEC4、PC1/3、PC4和PC5/6
可逆性：是
细胞可渗透性：是
包装
用惰性气体包装
警告
毒性：标准处理（A）
外形
作为三氟乙酸盐提供。
重悬
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
其他说明
Becker, G., et al. 2012.J Biol Chem287, 21992.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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