推荐产品
product name
HIV Inhibitor, CADA,
检测方案
≥98% (HPLC)
质量水平
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 10 mg/mL
water: insoluble
储存温度
−20°C
一般描述
A cell-permeable macrocyle cyclotriazadisulfonamide derivative compound that inhibits HIV replication (IC50 = 300 nM to 3.3 µM) and entry into cells by blocking co-translational translocation of nascent CD4 across endoplasmic reticulum membranes. Its action appears to be highly selective in reducing the expression of human CD4 and it does not affect the level of any other cell surface marker studied. Does not affect CD4 mRNA levels in cells. Shown to be effective against HIV-1 subtypes A to H, AE, and O and human herpesvirus 7 (HHV-7; IC50, 300 nM to 1.5 µM) in T-cell lines and PBMCs. Also reported to block X4 HIV-1 NL4.3 and R5 SIVmac251 laboratory strains infection in human T cells. Can act synergistically with cellulose acetate phthalate (CAP) and other anti-HIV drugs to inhibit HIV-1 and SIV infections.
生化/生理作用
Reversible: yes
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
其他说明
Vermeire, K., et al. 2008. Curr. HIV Res.6, 246.
Bell, T. W., et al. 2006. J. Med. Chem.49, 1291.
Vermeire, K., et al. 2004. AIDS.18, 2115.
Vermeire, K., et al. 2002. Virology.302, 342.
Bell, T. W., et al. 2006. J. Med. Chem.49, 1291.
Vermeire, K., et al. 2004. AIDS.18, 2115.
Vermeire, K., et al. 2002. Virology.302, 342.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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