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Merck
CN

5.31042

Fulvestrant

≥98% (HPLC), powder, GPR30 agonist, Calbiochem®

别名:

Estrogen Receptor Antagonist, ICI 182,780, GPR30 Agonist, ICI 182,780, ICI 182780, ICI182780

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关于此项目

经验公式（希尔记法）:
C32H47F5O3S
化学文摘社编号:
129453-61-8
分子量:
606.77
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00903953
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
OK to freeze, protect from light

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产品名称

Estrogen Receptor Antagonist, ICI 182,780,

storage temp.

2-8°C

SMILES string

FC(F)(F)C(F)(F)CCC[S](=O)CCCCCCCCC[C@H]1[C@H]2[C@H]3[C@@]([C@H](CC3)O)(CC[C@@H]2c4c(cc(cc4)O)C1)C

InChI

1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41?/m1/s1

InChI key

VWUXBMIQPBEWFH-WCCTWKNTSA-N

assay

≥98% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 100 mg/mL

Quality Level

100

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相关类别

General description

A cell-permeable estradiol derivative that acts as an estrogen antagonist and down-regulates estrogen receptors without affecting estrogen receptor-mediated progesterone receptor expression. Hence, it lacks estrogen agonist activity. Shown to be more effective than tamoxifen in reducing estrogen receptors in breast tumor cells. Suppresses the growth of MCF-7 xenografts in mice for twice as long as tamoxifen and delays tumor growth.



Please note that the molecular weight for this compound is batch-specific due to variable water content.
A cell-permeable estrogen antagonist. More effective than tamoxifen in reducing estrogen receptors in breast tumor cells.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
ER
Secondary Target
GPR30

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Wakeling, A. E., et al. 1991. Cancer Res.51, 3867.
Dauvois, S., et al. 1993. J. Cell. Sci.106, 1377.
Howell, A., et al. 1995. The Lancet.8941, 29.
Robertson, J.F., et al. 2001. J. Steroid Biochem. Mol Biol.79, 209.

Legal Information

Sold with the permission of AstraZeneca UK. Limited for research purposes only.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

wgk

WGK 3

pictograms

Health hazardEnvironment
GHS08,GHS09

signalword

Danger

flash_point_f

Not applicable

flash_point_c

Not applicable

Hazard Classifications

Aquatic Chronic 1 - Lact. - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

法规信息

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