推荐产品
方案
≥98% (HPLC)
质量水平
表单
powder
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
yellow
溶解性
DMSO: 50 mg/mL
储存温度
2-8°C
InChI
1S/C52H76O24/c1-18-29(72-34-14-30(43(58)21(4)68-34)73-33-13-28(54)42(57)20(3)67-33)12-26-10-25-11-27(49(66-9)48(63)41(56)19(2)53)50(47(62)39(25)46(61)38(26)40(18)55)76-36-16-31(44(59)23(6)70-36)74-35-15-32(45(60)22(5)69-35)75-37-17-52(8,65)51(64)24(7)71-37/h10,12,19-24,27-28,30-37,41-45,49-51,53-61,64-65H,11,13-17H2,1-9H3/t19-,20-,21-,22-,23-,24-,27+,28-,30-,31-,32-,33+,34+,35+,36+,37+,41+,42-,43-,44-,45-,49+,50+,51-,52+/m1/s1
InChI key
CFCUWKMKBJTWLW-WZIVUMCRSA-N
一般描述
An aureolic acid type tricyclic pentaglycoside antibiotics with anti-tumor properties. Binds to G-C rich DNA and displaces Sp1 transcription factor from its sites in the promoters of selected oncogenes, such as c-Myc and c-Src. Mithramycin A-induced inhibition of Sp1 activity has been linked to greater DNA damage and cell death in cells that are homozygous for SNP309. Specifically reduces the levels of MDM2 in human ductal breast epithelial tumor cell line, T47D (5-fold reduction at 200 nM), but does not affect cells that are wild-type for SNP309. Shown to induce myeloid differentiation of leukemic blasts that leads to reduction in the level of expression of c-Myc and c-Abl proto oncogenes that harbor G-C rich promoters. Inhibits Mcl-1 activity and mTOR phosphorylation (Ser2448) in prostate cancer cells without affecting normal human prostate epithelial cells. Shown to reduce expression of endogenous transient receptor potential vanilpod receptor (TRPV1)-like protein in dorsal root ganglionic neurons.
生化/生理作用
Primary Target
Sp1 transcription factor
Sp1 transcription factor
Reversible: yes
包装
Packaged under inert gas
警告
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Zavala, K., et al. 2014. Neurosci Lett.562,in press.
Choi, E. S., et al. 2013. J. Clin. Biochem. Nutr.53, 89.
Sleiman S. F., et al. 2011. J. Neurosci.31, 6858.
Bond, G, et al. 2004. Cell.119, 591.
Blume, S, et al. 1991. J. Clin. Invest.88, 1613.
Choi, E. S., et al. 2013. J. Clin. Biochem. Nutr.53, 89.
Sleiman S. F., et al. 2011. J. Neurosci.31, 6858.
Bond, G, et al. 2004. Cell.119, 591.
Blume, S, et al. 1991. J. Clin. Invest.88, 1613.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
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