推荐产品
方案
≥99% (HPLC)
质量水平
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
off-white
溶解性
DMSO: 10 mg/mL
运输
ambient
储存温度
−20°C
InChI
1S/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14/h4-11H,1-3H3,(H2,20,21,22)
InChI key
XSHQBIXMLULFEV-UHFFFAOYSA-N
一般描述
Src家族酪氨酸激酶的强效，可逆，ATP竞争性和细胞可渗透抑制剂，与野生型v-Src（IC50=1.0 µnM）相比，对I338G突变体v-Src（IC50 = 1.5 nM）的选择性高>800倍。也抑制野生型Fyn（IC50=600 nM）。 也有InSolution 格式（目录号529605）。
Src家族酪氨酸激酶的强效，可逆，ATP竞争性，细胞可渗透和选择性抑制剂，与野生型v-Src（IC50 = 1 µM）相比，对I338G突变体v-Src（IC50 = 1.5 nM）的选择性高>800倍。也抑制野生型Fyn（IC50=600 nM）。 也有InSolution 格式（目录号529605）。
生化/生理作用
主要靶标
I338G突变体v-Src
I338G突变体v-Src
产物与ATP竞争。
可逆性：是
细胞可渗透性：具有
靶标IC50：I338G突变体v-Src为1.5 nM；野生型v-Src为1.0 µM；野生型Fyn为600 nM
包装
用惰性气体包装
警告
毒性：标准处理（A）
重悬
在复溶后存放于冰箱（4°C）。储备溶液在4°C下可稳定保存3个月。
其他说明
Bishop, A.C., et al. 2000.Nature407, 395.
Bishop, A.C., et al. 1999 J. Am. Chem. Soc.121, 627.
Bishop, A.C., et al. 1999 J. Am. Chem. Soc.121, 627.
法律信息
不可在美国销售。
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
KangBo Ng et al.
microPublication biology, 2022 (2022-08-24)
Engineered analog sensitive kinases provide a highly effective method for acute, controllable, and highly selective inhibition of kinase activity. Here we describe the design and characterization of an analog sensitive allele of the polarity kinase, PKC-3. This allele supports normal
KangBo Ng et al.
Current biology : CB, 33(20), 4298-4311 (2023-09-21)
During development, the conserved PAR polarity network is continuously redeployed, requiring that it adapt to changing cellular contexts and environmental cues. In the early C. elegans embryo, polarity shifts from being a cell-autonomous process in the zygote to one that must
Nicolas Loyer et al.
eLife, 13 (2024-06-13)
The generation of distinct cell fates during development depends on asymmetric cell division of progenitor cells. In the central and peripheral nervous system of Drosophila, progenitor cells respectively called neuroblasts or sensory organ precursors use PAR polarity during mitosis to
Mai Usui et al.
Genes to cells : devoted to molecular & cellular mechanisms, 21(4), 302-310 (2016-01-27)
Brown adipocytes and beige adipocytes can expend energy, generate heat, and increase whole-body energy expenditure. The detailed mechanisms of adipogenesis and thermogenesis of these cells are still obscure. Here, we show that Src family kinases (SFKs) regulate both brown adipogenesis
Venkatesh Kundumani-Sridharan et al.
Arteriosclerosis, thrombosis, and vascular biology, 41(8), 2293-2314 (2021-05-28)
[Figure: see text].
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