528282
Polo-like Kinase Inhibitor I
The Polo-like Kinase Inhibitor I, also referenced under CAS 916985-21-2, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Polo-like Kinase Inhibitor I, 5-(5,6-Dimethoxybenzimidazol-1-yl)-3-(4-methanesulfonyl-benzyloxy)-thiophene-2-carboxamide, Plk Inhibitor I, Plk Inhibitor I, 5-(5,6-Dimethoxybenzimidazol-1-yl)-3-(4-methanesulfonyl-benzyloxy)-thiophene-2-carboxamide
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About This Item
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质量水平
方案
≥98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
tan
溶解性
DMSO: 10 mg/mL
运输
ambient
储存温度
2-8°C
InChI
1S/C22H21N3O6S2/c1-29-17-8-15-16(9-18(17)30-2)25(12-24-15)20-10-19(21(32-20)22(23)26)31-11-13-4-6-14(7-5-13)33(3,27)28/h4-10,12H,11H2,1-3H3,(H2,23,26)
InChI key
YYZTVTZCYVZGRB-UHFFFAOYSA-N
一般描述
A thiophenecarboxamide compound that acts as a potent and ATP-binding site-targeting inhibitor of polo-like kinase 1 (IC50 = 126 nM) with excellent selectivity over IKK-2 and IKK-3 (IC50 >16 µM).
生化/生理作用
Cell permeable: no
Primary Target
Polo-like Kinase
Polo-like Kinase
Product does not compete with ATP.
Reversible: no
Target IC50: 126 nM against polo-like kinase 1
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Bamborough, P., et al. 2006. Bioorg. Med. Chem. Lett.16, 6236.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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