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Merck
CN

527455

PKR Inhibitor, Negative Control

The PKR Inhibitor, Negative Control, also referenced under CAS 852547-30-9, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

别名:

PKR Inhibitor, Negative Control, RNA-Dependent Protein Kinase Inhibitor, Negative Control, 5-Chloro-3-(3,5-dichloro-4-hydroxybenzylidene)-1,3-dihydro-indol-2-one

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关于此项目

经验公式（希尔记法）:
C15H8Cl3NO2
化学文摘社编号:
852547-30-9
分子量:
340.59
MDL number:
MFCD09037552
UNSPSC Code:
12352200
NACRES:
NA.77

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产品名称

PKR Inhibitor, Negative Control, The PKR Inhibitor, Negative Control, also referenced under CAS 852547-30-9, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

SMILES string

Clc1c(c(cc(c1)C=C2c3c(ccc(c3)Cl)NC2=O)Cl)O

InChI

1S/C15H8Cl3NO2/c16-8-1-2-13-9(6-8)10(15(21)19-13)3-7-4-11(17)14(20)12(18)5-7/h1-6,20H,(H,19,21)

InChI key

ZJFMARHFPUZEKI-UHFFFAOYSA-N

assay

≥95% (sum of two isomers, HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 10 mg/mL
ethanol: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

相关类别

Biochem/physiol Actions

Cell permeable: no
Primary Target
A negative control for PKR Inhibitor
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

An oxindole compound that serves as a negative control for PKR Inhibitor (Cat. No. 527450). Shown to be inactive in inhibiting RNA-induced PKR autophosphorylation (IC50 >100 µM) or in rescuing PKR-dependent translation block.

Other Notes

Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun.308, 50.

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 1

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