527455
PKR Inhibitor, Negative Control
The PKR Inhibitor, Negative Control, also referenced under CAS 852547-30-9, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
PKR Inhibitor, Negative Control, RNA-Dependent Protein Kinase Inhibitor, Negative Control, 5-Chloro-3-(3,5-dichloro-4-hydroxybenzylidene)-1,3-dihydro-indol-2-one
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About This Item
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质量水平
方案
≥95% (sum of two isomers, HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
yellow
溶解性
DMSO: 10 mg/mL
ethanol: 10 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
Clc1c(c(cc(c1)C=C2c3c(ccc(c3)Cl)NC2=O)Cl)O
InChI
1S/C15H8Cl3NO2/c16-8-1-2-13-9(6-8)10(15(21)19-13)3-7-4-11(17)14(20)12(18)5-7/h1-6,20H,(H,19,21)
InChI key
ZJFMARHFPUZEKI-UHFFFAOYSA-N
一般描述
An oxindole compound that serves as a negative control for PKR Inhibitor (Cat. No. 527450). Shown to be inactive in inhibiting RNA-induced PKR autophosphorylation (IC50 >100 µM) or in rescuing PKR-dependent translation block.
An oxindole compound that serves as a negative control for PKR Inhibitor (Cat. No. 527450). Shown to be inactive in the inhibition of RNA-induced PKR autophosphorylation (IC50 >100 µM). Exhibits no ability to rescue the translational block imposed by human PKR.
生化/生理作用
Cell permeable: no
Primary Target
A negative control for PKR Inhibitor
A negative control for PKR Inhibitor
Product does not compete with ATP.
Reversible: no
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
其他说明
Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun.308, 50.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
Sanket S Ponia et al.
Cell reports, 37(4), 109888-109888 (2021-10-28)
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