推荐产品
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
purple
溶解性
DMSO: 6 mg/mL
运输
wet ice
储存温度
−20°C
一般描述
The racemic mixture of a pyridocarbazolo-cyclopentadienyl Ruthenium complex that acts as a ATP-binding site-targeting, reversible, and highly potent inhibitor of PIM-1 (IC50 = 0.5 and 3 nM for the (S)- and (R)-enantiomer, respectively) with ∼10-fold selectivity over GSK-3α (IC50 = 15 and 20 nM for the (S)- and (R)-enantiomer, respectively).
生化/生理作用
Cell permeable: no
Primary Target
PIM1
PIM1
Product does not compete with ATP.
Reversible: no
Target IC50: 0.5 and 3 nM for the (S)- and (R)-enantiomer, of PIM-1, respectively
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Bergman, H. and Meggers, E., 2006. Org. Lett.8, 5465.
法律信息
Sold for research purposes only, pursuant to an agreement with University of Pennsylvania.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Howard Bregman et al.
Organic letters, 8(24), 5465-5468 (2006-11-17)
Cyclopentadienyl half-sandwich ruthenium complexes have been demonstrated to be promising scaffolds as protein kinase inhibitors. In order to rapidly identify derivatives which display modified pharmacological properties, we developed the synthesis of an organoruthenium compound bearing an N-succinimidyl ester at the
Zhongde Ye et al.
NPJ aging and mechanisms of disease, 7(1), 4-4 (2021-02-10)
MicroRNAs play an important role in the regulation of T cell development, activation, and differentiation. One of the most abundant microRNAs in lymphocytes is miR-181a, which controls T cell receptor (TCR) activation thresholds in thymic selection as well as in
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