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质量水平
检测方案
≥99% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
pale yellow
溶解性
DMSO: 50 mg/mL
运输
ambient
储存温度
2-8°C
一般描述
一种可渗透细胞的联吡啶基丙烯酮化合物，以混合模式方式选择性阻断PFKFB3同工酶相对于PFK-1（6-磷酸果糖-1-激酶）的PFK-2（6-磷酸果糖-2-激酶）活性。迅速降低果糖2，6-二磷酸（F-2，6-P2）和2-脱氧葡萄糖的摄取以及乳酸盐的分泌；有效阻止转化细胞的增殖（NHBE-ht/LT/ras的IC50 ~ 1.4 µ M），并在几种异种移植小鼠模型中抑制肿瘤生长（70 mg/kg，i.p.）。显示3PO的细胞抑制作用和细胞毒性作用对F-6-P（果糖-6-磷酸）和F-2，6-P2的细胞内水平高度敏感。
包装
用惰性气体包装
警告
毒性：标准处理（A）
重悬
复溶后，等分并冷冻保存（-70°C）。贮备液在-70°C下可稳定保存至多6个月。
其他说明
Clem, B., et al. 2008.Mol.Cancer Ther.7, 110.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Brian Clem et al.
Molecular cancer therapeutics, 7(1), 110-120 (2008-01-19)
6-phosphofructo-1-kinase, a rate-limiting enzyme of glycolysis, is activated in neoplastic cells by fructose-2,6-bisphosphate (Fru-2,6-BP), a product of four 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isozymes (PFKFB1-4). The inducible PFKFB3 isozyme is constitutively expressed by neoplastic cells and required for the high glycolytic rate and anchorage-independent
Juliana Escher Toller-Kawahisa et al.
Nature communications, 14(1), 4280-4280 (2023-07-18)
Neutrophils rely predominantly on glycolytic metabolism for their biological functions, including reactive oxygen species (ROS) production. Although pyruvate kinase M2 (PKM2) is a glycolytic enzyme known to be involved in metabolic reprogramming and gene transcription in many immune cell types
Gangqi Wang et al.
Arteriosclerosis, thrombosis, and vascular biology, 40(2), 350-364 (2019-12-13)
Endothelial cells exposed to laminar shear stress express a thick glycocalyx on their surface that plays an important role in reducing vascular permeability and endothelial anti-inflammatory, antithrombotic, and antiangiogenic properties. Production and maintenance of this glycocalyx layer is dependent on
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