525185
Phospholipase C Activator, m-3M3FBS
The Phospholipase C Activator, m-3M3FBS, also referenced under CAS 200933-14-8, controls the biological activity of Phospholipase C. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
别名:
Phospholipase C Activator, m-3M3FBS, m-3M3FBS, 2,4,6-Trimethyl-N-( m-3-trifluoromethylphenyl)benzenesulfonamide, m-3M3FBS, 2,4,6-Trimethyl-N-(m-3-trifluoromethylphenyl)benzenesulfonamide
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About This Item
质量水平
检测方案
≥95% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
off-white
溶解性
DMSO: 7 mg/mL
运输
ambient
储存温度
2-8°C
InChI
1S/C16H16F3NO2S/c1-10-7-11(2)15(12(3)8-10)23(21,22)20-14-6-4-5-13(9-14)16(17,18)19/h4-9,20H,1-3H3
InChI key
ZIIUUSVHCHPIQD-UHFFFAOYSA-N
一般描述
A cell-permeable and specific activator of phospholipase C (PLC). Reported to stimulate PLC-mediated intracellular Ca2+ release, inositol phosphate production, and superoxide generation in various cell types. Activates all PLC isotypes (β2, β3, γ1, &gamma2, and δ1) in vitro, but does not exhibit any effect on heterotrimeric G proteins, PI 3-kinase, or phospholipase D.
A novel sulfonamide compound that acts as a cell-permeable and specific activator of phospholipase C (PLC). Shown to stimulate the PLC-mediated intracellular Ca2+ release, inositol phosphates production, and superoxide generation in various cell types. It activates all PLC isotypes (β2, β3, γ1, γ2, and δ1) in vitro, but not heterotrimeric G proteins, PI 3-kinase, or PLD.
生化/生理作用
Cell permeable: yes
Primary Target
Phospholipase C (PLC)
Phospholipase C (PLC)
Product does not compete with ATP.
Reversible: no
包装
Packaged under inert gas
警告
Toxicity: Carcinogenic / Teratogenic (D)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
其他说明
Bae, Y.S., et al. 2003. Mol. Pharmacol.63, 1043.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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The Journal of biological chemistry, 298(3), 101740-101740 (2022-02-20)
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