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524400

Sigma-Aldrich

佛波醇12-十四酸酯13-乙酸酯

≥98% (HPLC), solid, PKC activator, Calbiochem®

别名:

佛波醇12-十四酸酯13-乙酸酯, TPA，PMA，PKC活化剂I

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About This Item

经验公式（希尔记法）:
C36H56O8
CAS号:
16561-29-8
分子量:
616.83
MDL编号:
MFCD00036736
UNSPSC代码:
12352211
NACRES:
NA.77
价格与库存信息目前不能提供

产品名称

佛波醇12-十四酸酯13-乙酸酯, Phorbol-12-myristate-13-acetate, CAS 16561-29-8, is the most common phorbol ester. Activates PKC at nanomolar concentrations.

质量水平

100

描述

RTECS - QH4377000

方案

≥98% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze

颜色

white

溶解性

DMSO: 10 mg/mL

运输

ambient

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Tuner Competent Cells - Novagen Tuner host strains are lacZY deletion mutants of BL21, which enable adjustable levels of protein expression throughout all cells in a culture.

70622M

Tuner Competent Cells - Novagen

Tuner(DE3)pLysS Competent Cells - Novagen Tuner host strains are lacZY deletion mutants of BL21, which enable adjustable levels of protein expression throughout all cells in a culture. T7 lysozyme expression suppresses basal T7 expression.

70624

Tuner(DE3)pLysS Competent Cells - Novagen

Tuner (DE3) Competent Cells - Novagen® Tuner host strains are lacZY deletion mutants of BL21, which enable adjustable levels of protein expression throughout all cells in a culture.

70623

Tuner (DE3) Competent Cells - Novagen®

Rosetta 2(DE3)pLacI Competent Cells - Novagen Rosetta strains are BL21 derivatives designed to enhance the expression of eukaryotic proteins that contain codons rarely used in E. coli. Contains the pLacI plasmid producing extra Lac repressor.

71404M

Rosetta 2(DE3)pLacI Competent Cells - Novagen

technique(s)

microbiological culture: suitable

technique(s)

microbiological culture: suitable

technique(s)

microbiological culture: suitable

technique(s)

microbiological culture: suitable

growth mode

adherent or suspension

growth mode

adherent or suspension

growth mode

adherent or suspension

growth mode

adherent or suspension

morphology

rod shaped

morphology

rod shaped

morphology

rod shaped

morphology

rod shaped

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice, wet ice

shipped in

dry ice

一般描述

最常用的佛波醇酯。极强效的小鼠皮肤肿瘤促进剂。即使在nM浓度下也能在体内和体外激活蛋白激酶C。在培养的肝细胞中促进可诱导型NOS的表达。激活Ca2+-ATPase并增强毛喉素诱导的cAMP形成。抑制Fas抗原诱导的凋亡，但在HL-60早幼粒细胞白血病细胞中是诱导凋亡。它的结合是可逆的。还可以提供在DMSO（货号500582）中的10 mM溶液。

生化/生理作用

产物不与ATP竞争。
可逆性：是
细胞渗透性：否
首要靶标
蛋白激酶C

包装

用惰性气体包装

警告

毒性：有害（C）

制备说明

仅在使用前再用水相缓冲液进行稀释。

重悬

溶解后，等分并冷冻保存（-20°C）。无水DMSO储备液可在-20°C最长稳定6个月。DMSO储备液在频繁使用时可能会积水。储备液中存在的水将会加速产物的分解，导致在2-3个月内活性的明显下降。

其他说明

Powell, D.J., et al. 2003.Mol.Cell Biol.23, 7794.
Tepper, C.G., et al. 1995.Proc.Natl.Acad.Sci. USA92, 8443.
Oishi, K., and Yamaguchi, M. 1994.J. Cell.生物化学。55, 168.
Macfarlane, D.E., and O’Donnell, P.S.1993.Leukemia7, 1846.
Ghandi, V.C. and Jones, D.J., 1992.Neuropharmacol.31, 1101.
Hortelano, S., et al. 1992.J. Biol. Chem. 267, 24937.
Kontny, E., et al. 1992.Eur. J. Pharmacol.227, 333.
Zanaboni, P.B., et al. 1992.J. Appl. Physiol.73, 2011.
Saltis, J., et al. 1991.J. Biol. Chem.266, 261.
Beguinot, L., et al. 1985.Proc.Natl.Acad.Sci. USA82, 2774.
Perchellet, J. 1985.Carcinogenesis6, 567.
Nishizuka, Y. 1984.Science255, 1365.
Mastro, A. 1982.Lymphokines6, 263.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

警示用语：

Danger

危险分类

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

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