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Merck
CN
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文件

516566

Sigma-Aldrich

PPARγ Antagonist III, G3335

The PPARγ Antagonist III, G3335, also referenced under CAS 36099-95-3, controls the biological activity of PPARγ.

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别名:
PPARγ Antagonist III, G3335, H-Trp-Glu-OH
经验公式（希尔记法）:
C16H19N3O5
CAS号:
36099-95-3
分子量:
333.34
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

100

检测方案

≥98% (TLC)

形式

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

white

溶解性

water: 30 mg/mL

运输

ambient

储存温度

2-8°C

InChI

1S/C16H19N3O5/c17-11(7-9-8-18-12-4-2-1-3-10(9)12)15(22)19-13(16(23)24)5-6-14(20)21/h1-4,8,11,13,18H,5-7,17H2,(H,19,22)(H,20,21)(H,23,24)/t11-,13-/m0/s1

InChI key

PWIQCLSQVQBOQV-AAEUAGOBSA-N

一般描述

A cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist (KD = ~ 8 µM). Shown to inhibit the agonist activity of Rosiglitazone (100 nM) in a dose-dependent manner (IC50 = 31.9 µM) in transfected COS-7 cells.
A cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist (KD ~8 µM). Shown to inhibit the agonist activity of Rosiglitazone (100 nM) in a dose-dependent manner (IC50 = 31.9 µM) in transfected COS-7 cells.

生化/生理作用

Cell permeable: yes
Primary Target
PPARγ
Product does not compete with ATP.
Reversible: yes
kd = ~ 8 µM as PPARγ antagonist

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

制备说明

Addition of a small amount of acid or base may be required for complete solubilization.

重悬

Following reconstitution aliquot freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

其他说明

Ye, F., et al. 2006. Chembiochem7, 74.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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