513100
DL-threo-PDMP, Hydrochloride
PDMP closely resembles the natural sphingolipid substrate of brain glucosyltransferase and acts as a potent and competitive inhibitor of this enzyme.
别名:
DL-threo-PDMP, Hydrochloride, 1-Phenyl-2-decanoylamino-3-morpholino-1-propanol, HCl
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所有图片(1)
About This Item
经验公式（希尔记法）:
C23H38N2O3 · xHCl
CAS号:
分子量:
390.56 (free base basis)
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
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质量水平
方案
≥98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white
溶解性
DMSO: soluble
ethanol: soluble
methanol: soluble
运输
ambient
储存温度
−20°C
SMILES字符串
Cl.N2(CCOCC2)C[C@@H](NC(=O)CCCCCCCCC)[C@H](O)c1ccccc1
InChI
1S/C23H38N2O3.ClH/c1-2-3-4-5-6-7-11-14-22(26)24-21(19-25-15-17-28-18-16-25)23(27)20-12-9-8-10-13-20;/h8-10,12-13,21,23,27H,2-7,11,14-19H2,1H3,(H,24,26);1H/t21-,23-;/m1./s1
InChI key
HVJHJOYQTSEKPK-BLDCTAJRSA-N
一般描述
PDMP closely resembles the natural sphingolipid substrate of brain glucosyltransferase and acts as a potent and competitive inhibitor of this enzyme. Blocks the outgrowth of neurites and inhibits glycolipid synthesis in cultured NIH/3T3 cells.
PDMP closely resembles the natural sphingolipid substrate of brain glucosyltransferase and is a potent and competitive inhibitor of this enzyme. Blocks the outgrowth of neurites and inhibits glycolipid synthesis in cultured 3T3 cells.
生化/生理作用
Cell permeable: no
Primary Target
glycolipid synthesis in cultured NIH/3T3 cells
glycolipid synthesis in cultured NIH/3T3 cells
Product does not compete with ATP.
Reversible: no
警告
Toxicity: Irritant (B)
其他说明
Rani, C.S., et al. 1995. J. Biol. Chem. 270, 2859.
Rosenwald, A.G. 1992. Biochemistry31, 3581.
Inokuchi, J., and Radin, N.S. 1987. J. Lipid Res.28, 565.
Vunnam, R.R., and Radin, N.S. 1980. Chem. Phys. Lipids26, 265.
Rosenwald, A.G. 1992. Biochemistry31, 3581.
Inokuchi, J., and Radin, N.S. 1987. J. Lipid Res.28, 565.
Vunnam, R.R., and Radin, N.S. 1980. Chem. Phys. Lipids26, 265.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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