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检测方案
≥95% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
orange
溶解性
DMSO: 200 mg/mL
methanol: 5 mg/mL
储存温度
−20°C
InChI
1S/C11H8FNO2S/c12-7-1-2-9-8(4-7)6(5-13-9)3-10(16)11(14)15/h1-5,13,16H,(H,14,15)/b10-3-
InChI key
HWMQHECFXSVZGN-KMKOMSMNSA-N
一般描述
A cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain. Displays over 20-fold greater selectivity for µ-calpain (Calpain I) over m-calpain (Calpain II) (Ki values, 260 nM and 5.33 µM, respectively). Has been shown to prevent cycloheximide induced apoptosis.
A cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain. Displays over 20-fold greater selectivity for calpain-1 (Cat. Nos. 208712 and 208713) over calpain-2 (Cat. Nos. 208715 and 208718) (Ki values: 260 nM and 5.33 µM, respectively). Has been shown to prevent cycloheximide-induced apoptosis.
生化/生理作用
Primary Target
calpain-1
calpain-1
Target Ki: 260 nM against calpain-1
警告
Toxicity: Standard Handling (A)
重悬
Unstable in solution; reconstitute just prior to use.
其他说明
Squier, M.K., et al. 1999. J. Cell Physiol.178, 311.
Wang, K.K., et al. 1996. Proc. Natl. Acad. Sci. USA93, 6687.
Wang, K.K., et al. 1996. Proc. Natl. Acad. Sci. USA93, 6687.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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