5.08839
BIBR1532
≥98% (HPLC), solid, telomerase inhibitor, Calbiochem®
别名:
Telomerase Inhibitor X, BIBR1532, BIBR 1532, BIBR-1532
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关于此项目
经验公式（希尔记法）:
C21H17NO3
化学文摘社编号:
分子量:
331.36
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
产品名称
Telomerase Inhibitor X, BIBR1532,
SMILES string
N(c3c(cccc3)C(=O)O)C(=O)\C=C(/C)\c1cc2c(cc1)cccc2
InChI
1S/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+
InChI key
PGFQXGLPJUCTOI-WYMLVPIESA-N
assay
≥98% (HPLC)
form
solid
potency
93 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white
solubility
DMSO: 100 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Teomerase
Teomerase
Reversible: yes
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell-permeable benzoic acid based compound that acts as a selective, highly potent, non-nucleotide competitive inhibitor of the catalytic activity of telomerase (IC50 = 93 nM in HeLa cells nuclear extracts). Also shown to be effective against recombinant, affinity purified telomerase. Blocks the growth and proliferation of HeLa cells (~ 20 µM) by inducing apoptosis. The inhibition appears to be more prominent in TEL patch mutant cell lines. Causes a continuous erosion of telomeres in multiple human cancer cell lines. Does not affect the activity of DNA and RNA polymerases in any significant manner.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Other Notes
Damm, K., et al. 2001. The. EMBO J.20, 6958.
Pascolo, E., et al. 2002. J. Biol. Chem.277,15566.
Nakashima, M., et al. 2013. J. Biol. Chem.288, 33171.
Pascolo, E., et al. 2002. J. Biol. Chem.277,15566.
Nakashima, M., et al. 2013. J. Biol. Chem.288, 33171.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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