5.08773
PPACK, 2HCl
InSolution, ≥88%
别名:
InSolution PPACK, 2HCl, D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone, 2HCl, H-D-Phe-Pro-Arg-chloromethylketone, 2HCl, PPACK, dihydrochloride InSolution
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About This Item
经验公式（希尔记法）:
C21H31ClN6O3 · 2HCl
分子量:
523.88
UNSPSC代码:
12352202
NACRES:
NA.77
推荐产品
![PPACK二盐酸盐 PPACK, Dihydrochloride, CAS 82188-90-7, is an extremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 10⁷M⁻¹S⁻¹). Reacts with thrombin in a 1:1 stoichiometry.](/deepweb/assets/sigmaaldrich/product/images/403/286/e04cdb4e-07b0-4353-b8e5-13b915eae16c/640/e04cdb4e-07b0-4353-b8e5-13b915eae16c.jpg)
质量水平
方案
≥88% (HPLC)
表单
liquid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
avoid repeated freeze/thaw cycles
protect from light
储存温度
−70°C
一般描述
D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone (PPACK) is a potent and specific inhibitor of thrombin with ideal, unbiased properties for use as an anticoagulant in blood gas, electrolyte, and iCa analyses.
生化/生理作用
Reversible: no
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
外形
A 25 mM (5 mg/357 µl) sterile-filtered solution of PPACK, 2HCl (Cat. No. 520222) in H₂O.
重悬
Following reconstitution, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
其他说明
Rosado, J. A., et al. 2002. J. Biol. Chem.277, 42157.
Odake S., et al. 1995. J. Enzyme Inhib.9, 17.
Arni, R.K., et al. 1993. Biochemistry32, 4727.
Yamashita, T., et al. 1993. Thromb. Res.69, 93.
Schmaier, A.H., et al. 1992. Thromb. Res.67, 479.
Collen, D., et al. 1982. J. Lab. Clin. Med.99, 76.
Kettner, C., and Shaw, E. 1981. Methods Enzymol.80, 826.
Kettner, C., and Shaw, E. 1979. Thromb. Res.14, 969.
Odake S., et al. 1995. J. Enzyme Inhib.9, 17.
Arni, R.K., et al. 1993. Biochemistry32, 4727.
Yamashita, T., et al. 1993. Thromb. Res.69, 93.
Schmaier, A.H., et al. 1992. Thromb. Res.67, 479.
Collen, D., et al. 1982. J. Lab. Clin. Med.99, 76.
Kettner, C., and Shaw, E. 1981. Methods Enzymol.80, 826.
Kettner, C., and Shaw, E. 1979. Thromb. Res.14, 969.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
法规信息
常规特殊物品
M E Lyon et al.
Clinical chemistry, 41(7), 1038-1041 (1995-07-01)
D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone (PPACK), a selective thrombin inhibitor, was evaluated as an alternative anticoagulant to lithium heparin (LiHep) for blood gas and whole-blood electrolyte analyses. Initial studies in serum revealed a negative proportional bias for ionized calcium (iCa) concentration measured
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