推荐产品
方案
≥98% (HPLC)
质量水平
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
water: 100 mM
储存温度
2-8°C
SMILES字符串
Cl.[n]1([c](cc(nc1C)N(CC)c2ccccc2)=NC)C
InChI
1S/C15H20N4.ClH/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;/h6-11H,5H2,1-4H3;1H
InChI key
DUWKUHWHTPRMAP-UHFFFAOYSA-N
一般描述
ZD7288 is a potent HCN blocker of hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels) in heart and brain tissue. Recently shown to also block Na+ currents in DRG neurons and in HEK293 cells transfected with Na(v)1.4 plasmids. In voltage clamp experiments, it is shown to reduce Ih in a time- and concentration-dependent manner (IC50 = 2 mM). Suggested to behave as a lipophilic quaternary cation that can pass into the cell interior to block Ih channels in their closed state.
生化/生理作用
Primary Target
HCN channel
HCN channel
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Pleasenote that the molecular weight for this compound is batch-specific due tovariable water content.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Xing Wu et al.
Channels (Austin, Tex.), 6(6), 438-442 (2012-09-20)
ZD7288 has been widely used as a tool in the study of hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels), and to test the relationships between HCN channels and heart and brain function. ZD7288 is widely considered a selective blocker of HCN
N C Harris et al.
Journal of neurophysiology, 74(6), 2366-2378 (1995-12-01)
1. The effects of the novel bradycardic agent 4-(N-ethyl-N-phenylamino)-1,2-dimethyl-6-(methylamino) pyrimidinium chloride (ZD 7288) (Zeneca) were investigated on the hyperpolarization-activated cationic current (Ih) in guinea pig substantia nigra pars compacta neurons in vitro, using a single-microelectrode current-clamp/voltage-clamp technique. 2. Under current-clamp
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