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方案
≥98% (HPLC)
质量水平
表单
solid
效能
8 nM IC50
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 100 mM
ethanol: 25 mM
储存温度
2-8°C
InChI
1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)
InChI key
VHKBTPQDHDSBSP-UHFFFAOYSA-N
一般描述
A voltage gated sodium channel type 1.8 (Nav1.8) pore blocker. Potently blocks tetrodotoxin-resistant currents (IC50) = 140 nM) and the generation of spontaneous and electrically evoked action potentials in vitro in rat dorsal root ganglion neurons. In recombinant cell lines, A-803467 potently blocked human Nav1.8 (IC50 = 8 nM) and was >100-fold selective vs. human Nav1.2, Nav1.3, Nav1.5, and Nav1.7 (IC50 values ≥ 1 µM).
生化/生理作用
Primary Target
Nav1.8
Nav1.8
警告
Toxicity: Standard Handling (A)
其他说明
Jarvis, M. F. et al. 2007. Proc. Natl. Acad. Sci. USA104, 8520.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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