5.08148
Nefazodone Hydrochloride
别名:
Nefazodone Hydrochloride, 5-HT 2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone, 5-HT2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone
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所有图片(1)
About This Item
经验公式（希尔记法）:
C25H32ClN5O2 · xHCl
CAS号:
分子量:
470.01 (free base basis)
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
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方案
≥99% (HPLC)
质量水平
表单
solid
效能
26 nM Ki
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
ethanol: 10 mM
DMSO: 25 mM
储存温度
2-8°C
SMILES字符串
Clc1cc(ccc1)N2CCN(CC2)CCC[n]3nc([n]([c]3=O)CCOc4ccccc4)CC.Cl
InChI
1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6,8-11,20H,2,7,12-19H2,1H3;1H
InChI key
DYCKFEBIOUQECE-UHFFFAOYSA-N
一般描述
A potent 5-HT2A receptor antagonist (Kd = 26 nM), with moderate affinity for the alpha1-adrenergic receptor (Kd = 48 nM) and 5-HT1A receptor (Kd = 80 nM). Originally developed as a clinical antidepressant but discontinued in 2004, nefazodone (Serzone) still remains a specific inhibitor of certain serotonergic pathways. Nefazodone also has been reported to induce mitochondrial dysfuntion.
警告
Toxicity: Standard Handling (A)
其他说明
Kim, J.-A. et al. 2012. Toxicol. Lett.214, 175.
Cusack, B. et al. 1994. Psychopharmacol.114, 559.
Cusack, B. et al. 1994. Psychopharmacol.114, 559.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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