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Merck
CN

506350

Pam₃Cys-Ser-（Lys）₄，盐酸盐

≥90% (HPLC), lyophilized solid, TLR1/TLR2 agonist, Calbiochem®

别名:

Pam₃Cys-Ser-（Lys）₄，盐酸盐, （S）-[2，3-双（棕榈酰氧基）-（2-RS）-丙基]-N-棕榈酰-（R）-Cys-（S）-Ser-（S）-Lys₄-OH，3HCl，P₃CSK₄，3HCl，Pam₃Cys-SK₄，3HCl，Pam3CSK4，TLR1/TLR2激动剂I

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关于此项目

经验公式（希尔记法）:
C81H156N10O13S · 3HCl
化学文摘社编号:
112208-00-1
分子量:
1619.61
MDL number:
MFCD06801383
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥90% (HPLC)
Form:
lyophilized solid
Quality level:
100
Storage condition:
OK to freeze
desiccated

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产品名称

Pam₃Cys-Ser-（Lys）₄，盐酸盐,

SMILES string

S(C[C@H](NC(=O)CCCCCCCCCCCCCCC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)CC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC

InChI

1S/C81H156N10O13S/c1-4-7-10-13-16-19-22-25-28-31-34-37-40-55-73(93)86-72(65-105-64-66(104-75(95)57-42-39-36-33-30-27-24-21-18-15-12-9-6-3)63-103-74(94)56-41-38-35-32-29-26-23-20-17-14-11-8-5-2)80(100)91-71(62-92)79(99)89-68(52-44-48-59-83)77(97)87-67(51-43-47-58-82)76(96)88-69(53-45-49-60-84)78(98)90-70(81(101)102)54-46-50-61-85/h66-72,92H,4-65,82-85H2,1-3H3,(H,86,93)(H,87,97)(H,88,96)(H,89,99)(H,90,98)(H,91,100)(H,101,102)/t66?,67-,68-,69-,70-,71-,72-/m0/s1

InChI key

OEDPHAKKZGDBEV-GFPBKZJXSA-N

assay

≥90% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

solubility

water: 2 mg/mL

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

相关类别

Application

PamCys-Ser-(Lys)盐酸盐可用于刺激 MODE-K 细胞，了解其对上皮神经纤毛蛋白-1 (NRP1) 蛋白表达的影响。它可用作 Toll 样受体 2 (TLR2) 配体，研究 TLR2 功能。

Disclaimer

毒性：标准处理（A）

General description

Pam3CSK4 是一种选择性 Toll 样受体 1/2 (TLR1/2) 激动剂，用于研究 TLR1/2 功能。它是 TLR1/2 的合成脂肽，模仿细菌脂肽的酰化氨基末端。 Pam3CSK4 具有三条脂质链，可促进受体异二聚化。两条酯结合脂质链插入 TLR2 中的口袋中，而酰胺结合脂质链插入 TLR1 中的疏水通道中。在人类葡萄膜炎、眼内炎和实验性葡萄膜炎模型背景下，Pam3CSK4 可触发眼内液和/或组织中的各种细胞因子和趋化因子表达和分泌。 一种能有效激活单核细胞和巨噬细胞的细菌脂蛋白免疫活性N端部分的可渗透细胞的水溶性合成阳离子脂六肽类似物。诱导IL-1、IL-6、TNF-α、超氧化物和NO的释放。促进NF-κB的易位，增强酪氨酸蛋白磷酸化和ERK1/2和MEK1/2的活化。

Other Notes

Barrenschee, M., et al. 2010.PLoS One.5, e13889.
Zahringer, U., et al. 2008.Immunology.213, 205.
Toshchakov, V., et al. 2002.Nat. Immunol.3, 392.
Muller, M.R., et al. 2001.Immunology103, 49.
Vergne, I., and Cezanne, L. 1999.Eur. J. Biochem.264, 369.
Diaz-Guerra, M.J., et al. 1996.J. Biol. Chem.271, 30114.
Offermanns, S., et al. 1992.Biochem.J.282, 551.
Seifert, R., et al. 1990.Biochem.J.267, 795.
Hoffmann, P., et al. 1989.Biol. Chem. Hoppe.Seyler.370, 575.

Preparation Note

复溶后，等分并冷冻保存（-20°C）。避免溶液反复冻融。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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