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安全信息

5.06272

Sigma-Aldrich

SB 206553 Hydrochloride

别名:

SB 206553 Hydrochloride, 5-HT 2C Serotonin Receptor Antagonist, SB 206553, 5-HT 2B Serotonin Receptor Antagonist, SB 206553, SB206553, SB-206553

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About This Item

经验公式（希尔记法）:
C17H16N4O · xHCl
CAS号:
158942-04-2
分子量:
292.34 (free base basis)
MDL编号:
MFCD00928314
UNSPSC代码:
12352200
NACRES:
NA.77

方案

≥99% (HPLC)

质量水平

100

表单

solid

效能

3.2 nM Ki

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

yellow

溶解性

DMSO: soluble

储存温度

2-8°C

SMILES字符串

[n]1(c2c(cc3c(c2)CCN3C(=O)Nc4cnccc4)cc1)C

InChI

1S/C17H16N4O/c1-20-7-4-12-10-16-13(9-15(12)20)5-8-21(16)17(22)19-14-3-2-6-18-11-14/h2-4,6-7,9-11H,5,8H2,1H3,(H,19,22)

InChI key

QJQORSLQNXDVGE-UHFFFAOYSA-N

一般描述

A selective 5-HT2C serotonin receptor inhibitor with lesser affinity for 5-HT2BR. Often used in conjunction with ketanserin to distinguish 5-HT2AR and 5-HT2CR activity. SB206553 has highest affinity for 5-HT2CR (Ki = 3.2nM) and less for 5-HT2BR (Ki = 5.5 nM) and 5-HT2AR (Ki = 2,300 nM).
A selective 5-HT2C serotonin receptor inhibitor with lesser affinity for 5-HT2BR. Often used in conjunction with ketanserin to distinguish 5-HT2AR and 5-HT2CR activity. SB206553 has highest affinity for 5-HT2CR (Ki = 3.2nM) and less for 5-HT2BR (Ki = 5.5 nM) and 5-HT2AR (Ki = 2,300 nM).

生化/生理作用

Primary Target
5-HT2C
Secondary Target
5-HT2B

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Ros, R. et al. 2013. PNAS.110, 348.

Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.
Cussac, D. et al. 2002. Naunyn Schmiedebergs Arch. Pharmacol.365, 242.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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