5.06188
Sertraline Hydrochloride
别名:
Sertraline Hydrochloride, Serotonin (5-HT) Reuptake Inhibitor, Sertraline, Zoloft
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关于此项目
经验公式（希尔记法）:
C17H17Cl2N · xHCl
化学文摘社编号:
分子量:
306.23 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
[Cl-].Clc1c(ccc(c1)[C@@H]2CC[C@@H](c3c2cccc3)[N+H2]C)Cl
InChI
1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
InChI key
BLFQGGGGFNSJKA-XHXSRVRCSA-N
assay
≥99% (HPLC)
form
solid
potency
3.3 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 100 mM
ethanol: 50 mM
storage temp.
2-8°C
Quality Level
Disclaimer
Toxicity: Standard Handling (A)
Biochem/physiol Actions
Primary Target
5-HT uptake transporter
5-HT uptake transporter
General description
A very potent uptake inhibitor highly selective for serotonin (Ki = 3.3 nM). Clinically prescribed as an antidepressant drug. Often used in studying major depressive disorders.
Other Notes
Brunoni, R., et al. 2013. JAMA Psychiatry.70, 383.
Kobayashi, K., et al. 1995. Br. J. Clin. Pharmacol.40, 481.
Heym, J., et al. 1988. J. Clin. Psychiatry.49 Suppl, 40.
Koe, K., et al. 1983. J. Pharmacol. Exp. Ther.226, 700.
Kobayashi, K., et al. 1995. Br. J. Clin. Pharmacol.40, 481.
Heym, J., et al. 1988. J. Clin. Psychiatry.49 Suppl, 40.
Koe, K., et al. 1983. J. Pharmacol. Exp. Ther.226, 700.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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