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Merck
CN

506181

p75 NTR 信号抑制剂，细胞渗透性，TAT-Pep5

The p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 controls the biological activity of p75NTR. This small molecule/inhibitor is primarily used for Neuroscience applications.

别名:

p75 NTR 信号抑制剂，细胞渗透性，TAT-Pep5

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关于此项目

经验公式（希尔记法）:
C150H227N57O32S2
分子量:
3404.90
NACRES:
NA.77
UNSPSC Code:
12352202
Assay:
≥95% (HPLC)
Form:
lyophilized solid
Quality level:
100
Storage condition:
OK to freeze
desiccated (hygroscopic)
protect from light

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产品名称

p75 NTR 信号抑制剂，细胞渗透性，TAT-Pep5, The p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 controls the biological activity of p75NTR. This small molecule/inhibitor is primarily used for Neuroscience applications.

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

相关类别

Biochem/physiol Actions

主要靶标
MAG和Nogo诱导的神经突生长抑制的阻滞剂
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有

Disclaimer

毒性：标准处理（A）

General description

通过将p75NTR抑制剂Pep5（目录号506180）与来自HIV蛋白TAT的N端蛋白转导结构域序列（11个氨基酸）融合，使其具有细胞渗透性。在DRG（背根神经节）和产后小脑神经元中，显示作为MAG-和Nogo诱导的神经突生长抑制的有效阻滞剂。抑制中枢神经系统再生的潜在治疗剂。

Other Notes

H₂N-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys¹²-Phe-Phe-Arg-Gly-Gly-Phe-Phe-Asn-His-Asn-Pro-Arg-Tyr-Cys²⁶-OH

二硫键（12-26）
Yamashita, T., and Tohyama, M. 2003.Nat. Neurosci.6, 461.
Schwarze, S.R., et al. 1999.Science285, 1569.

Packaging

用惰性气体包装

Physical form

作为三氟乙酸盐提供。

Preparation Note

复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多1个月。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Ryo Uetsuki et al.
Biochemistry and biophysics reports, 26, 101003-101003 (2021-05-28)
The low-affinity nerve growth factor receptor p75 is a stratified epithelial stem/progenitor marker of human epithelia. We found OM-1, a human squamous cell carcinoma (SCC) cell line, showed distinct cells with p75 cluster, especially located at the center of a
Wei Sun et al.
Frontiers in cell and developmental biology, 10, 1018586-1018586 (2022-11-29)
Prenatal exposure to maternal infection increases the risk of offspring developing schizophrenia in adulthood. Current theories suggest that the consequences of MIA on mBDNF secretion may underlie the increased risk of cognitive disorder. There is little evidence for whether the
Xinxin Zhou et al.
Molecular pain, 16, 1744806920922100-1744806920922100 (2020-05-02)
HIV-associated neuropathic pain (HNP) is a common complication for AIDS patients. The pathological mechanism governing HNP has not been elucidated, and HNP has no effective analgesic treatment. Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family related

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